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Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells.
This study was focused on investigating the effect of small interfering RNA (siRNA)-mediated eIF3c gene knockdown on colon cancer cell survival. The eIF3c gene was observed to be highly expressed in colon cancer cell models. The expression levels of the gene in eIF3c siRNA infected and control siRNA infected cells were compared via real-time polymerase chain reaction (PCR) and western blotting analysis. Cell proliferation levels were analyzed employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Furthermore, the effects of eIF3c gene knockdown on the cell cycle and apopto...
Source: J Zhejiang Univ Sci ... - June 1, 2013 Category: Science Authors: Song N, Wang Y, Gu XD, Chen ZY, Shi LB Tags: J Zhejiang Univ Sci B Source Type: research

A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA.
Abstract Colon cancer is a type of malignant tumor that causes considerable mortality worldwide. Epithelial cellular adhesion molecule (EpCAM), a tumor-associated antigen of colon tumors, is a target for colon cancer therapy. EpCAM-specific monoclonal antibodies (mAbs) have been applied in human colon cancer since the 1990s; however, the therapeutic effects are limited. EpCAM activates nuclear signaling pathways by releasing its intracellular domain (EpICD). The released EpICD stimulates the Wnt/β-catenin signaling pathway, which is also strongly associated with tumorigenesis. EpCAM is also a target gene of the W...
Source: Cell Biology International - April 10, 2013 Category: Cytology Authors: Hao H, Zhen Y, Wang Z, Chen F, Xie X Tags: Cell Biol Int Source Type: research

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