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Cancer: Neuroblastoma
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Total 288 results found since Jan 2013.
4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway
Neurotoxicology. 2022 Apr 23;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Online ahead of print.ABSTRACTProlonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. Sevoflurane treatment significantly decreased the cel...
Source: Neurotoxicology - April 26, 2022 Category: Neurology Authors: Jingjing Lv Hao Cheng Weidong Yao Can Liu Yongquan Chen Xiaoju Jin Zeyong Yang Yuanhai Li Source Type: research
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma
Neuroblastoma (NB) is a devastating malignancy threatening children’s health, and amplification of MYCN is associated with treatment failure and a poor outcome. Here, we aimed to demonstrate the role of cell division cycle 27 (CDC27), an important core subunit of the anaphase-promoting complex, and its clinical significance in NB patients. In functional assays, we illustrated that CDC27 promoted the cell growth, metastasis and sphere-formation ability of NB cells both in vitro and in vivo. To further understand the potential mechanism, SK-N-SH cells were transfected with CDC27 siRNA, and RNA-sequencing was performed. The...
Source: Frontiers in Oncology - February 15, 2022 Category: Cancer & Oncology Source Type: research
Single-copy Loss of Rho Guanine Nucleotide Exchange Factor 10 ( < em > arhgef10 < /em > ) Causes Locomotor Abnormalities in Zebrafish Larvae
CONCLUSION: Based on our findings, ARHGEF10 appeared to have a haploinsufficiency effect.PMID:35078560 | DOI:10.3967/bes2022.005
Source: Biomedical and Environmental Sciences : BES - January 26, 2022 Category: Biomedical Science Authors: Yi Zhang Ming Xing An Chen Gong Yang Yang Li Yu Tong Wang Meng Lin Rong Li Chan Tian Source Type: research
