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Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

Natural product HTP screening for evidence of attenuated cytokine-induced neutrophil chemo attractants (CINCs) and NO2 − in LPS/IFNγ activated glioma cells
Chronic or acute central nervous system (CNS) inflammation is carried out by glial cells, which can contribute to neurological injuries associated with head trauma, stroke, and infection, Parkinson's or Alzheimer's disease. The process of aging combined with inflammation are also risk factors for developing glioblastoma multiforme (GBM) as well as perpetuating its malignant aggression. With growing public curiosity in complementary and alternative medicines (CAMs), in this work we conduct a high throughput (HTP) screening of>1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lip...
Source: Journal of Neuroimmunology - December 1, 2016 Category: Allergy & Immunology Authors: Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Taka Equar, Karam F.A. Soliman Source Type: research

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2 − in LPS/IFNγ activated glioma cells
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of>1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFN γ) activated C6 glioma cells.
Source: Journal of Neuroimmunology - December 1, 2016 Category: Allergy & Immunology Authors: Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, Karam F.A. Soliman Source Type: research