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From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives
The absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as the primary control measure against malaria. However, the emergence and spread of parasite resistance to conventional antimalarial drugs result in a worrisome scenario making the search for new drugs a priority. In the present study, the activities of nine neolignan derivatives were evaluated as follows: (i) against blood forms of chloroquine‐resistant Plasmodium falciparum (clone W2), using the tritiated hypoxanthine incorporation and anti‐HRPII assays; (ii) for cytotoxic activi...
Source: Chemical Biology and Drug Design - April 6, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: RESEARCH ARTICLE Source Type: research

Synthesis, antimalarial activity in vitro and docking studies of novel neolignan derivatives
This article is protected by copyright. All rights reserved. Synthesis and docking studies of new neolignan derivatives with antimalarial activity.
Source: Chemical Biology and Drug Design - February 27, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: Research Article Source Type: research