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The deactivation of signal transducer and activator of transcription‐3 activation signaling by emodin inhibits growth and induces apoptosis in orthotopic hepatocellular carcinoma model
Conclusions and ImplicationsOverall, our results suggest that emodin is mediating its effects predominantly through inhibition of STAT3 signaling cascade and thus has an enormous potential for the treatment cancers harboring constitutively activated STAT3.
Source: British Journal of Pharmacology - July 15, 2013 Category: Drugs & Pharmacology Authors: Aruljothi Subramaniam, Muthu K. Shanmugam, Tina H. Ong, Feng Li, Ekambaram Perumal, Luxi Chen, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Kam M Hui, Gautam Sethi Tags: Research Paper Source Type: research

Down-regulation of ANXA7 decreases metastatic potential of human hepatocellular carcinoma cells in vitro.
We report for the first time the influence of ANXA7 gene on human hepatocellular carcinoma cells (HCC). We down-regulated ANXA7 in human HCC cell line (HepG2) using siRNA method. By Western Blot analysis, we confirmed about 70% down-regulation of the gene in the shRNA-ANXA7 transfected cells (shRNA-ANXA7-HepG2) compared to the non-specific sequence shRNA transfected cells (control-shRNA-HepG2) and the un-manipulated-HepG2 cells. We used CCK-8 cell proliferation kit and observed about 65% reduction in the shRNA-ANXA7-HepG2 cells where the two controls exhibited comparable cell proliferation rates. Also, by using PI staining...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2013 Category: Drugs & Pharmacology Authors: Ibrahim MM, Sun MZ, Huang Y, Jun M, Jin Y, Yue D, Jiasheng W, Zhang J, Qazi AS, Sagoe K, Tang J Tags: Biomed Pharmacother Source Type: research

Synergistic induction of TRAIL-mediated apoptosis by anisomycin in human hepatoma cells via the BH3-only protein Bid and c-Jun/AP-1 signaling pathway.
Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF super-family, and it has been shown that many human cancer cell lines are refractory to TRAIL-induced cell death. However, the molecular mechanisms underlying resistance are unclear. In the present study, we show that TRAIL-resistance is reversed in human hepatoma cells by anisomycin, which is known to inhibit protein synthesis and induce ribotoxic stress. Synergistic induction of apoptosis in cells treated with anisomycin plus TRAIL was associated with activation of caspases and cleavage of Bid, a pro-apoptotic B...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2013 Category: Drugs & Pharmacology Authors: Jin CY, Park C, Hong SH, Han MH, Jeong JW, Xu H, Liu H, Kim GY, Kim WJ, Yoo YH, Choi YH Tags: Biomed Pharmacother Source Type: research

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells
In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma.
Source: Phytomedicine - March 28, 2013 Category: Drugs & Pharmacology Authors: Ming-Der Shi, Yi-Chen Liao, Yuan-Wei Shih, Li-Yu Tsai Tags: Oncology and Hematology Source Type: research

Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Abstract All-trans retinoic acid (atRA) is the active form of vitamin A, known to activate retinoid receptors, especially the heterodimer retinoid X receptor (RXR):retinoic acid receptor (RAR) that otherwise may play a role in regulation of some drug transporters. The present study was designed to characterize the nature of human hepatic transporters that may be targeted by atRA and the heterodimer RXR:RAR. Exposure of human hepatoma HepaRG cells and primary human hepatocytes to 5 μM atRA down-regulated mRNA levels of various sinusoidal solute carrier (SLC) influx transporters, including organic anion transportin...
Source: European Journal of Pharmaceutical Sciences - January 22, 2013 Category: Drugs & Pharmacology Authors: Le Vee M, Jouan E, Stieger B, Fardel O Tags: Eur J Pharm Sci Source Type: research

Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.
In this study, we studied the influence of omentin-1 on two types of human hepatocellular carcinoma cells: HepG2 and HuH-7 cells. Cell viability assay showed that omentin-1 (1 and 2μg/ml) significantly inhibited the proliferation of HepG2 and HuH-7 cells. Both annexin+PI staining and TUNEL assay showed that omentin-1 induced apoptosis in these cells. Moreover, omentin-1 treatment upregulated protein levels of p53 and p21, a main transcriptional target of p53. Interestingly, omentin-1 did not affect p53 mRNA level. Further mechanism study showed that omentin-1 upregulated p53 protein level through decreasing p53 deacetylat...
Source: European Journal of Pharmacology - January 5, 2013 Category: Drugs & Pharmacology Authors: Zhang YY, Zhou LM Tags: Eur J Pharmacol Source Type: research

Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma.
In conclusion, inhibition of CIP2A determines the effects of erlotinib on apoptosis in HCC. CIP2A may be useful as a therapeutic biomarker for predicting clinical response to erlotinib in HCC treatment. PMID: 23178652 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - November 23, 2012 Category: Drugs & Pharmacology Authors: Yu HC, Chen HJ, Chang YL, Liu CY, Shiau CW, Cheng AL, Chen KF Tags: Biochem Pharmacol Source Type: research

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