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Clinico-pathological characteristics of IGFR1 and VEGF-A co-expression in early and locally advanced-stage lung adenocarcinoma
CONCLUSIONS: These results suggest that IGFR1+&VEGF-A+ is expected to be a disadvantageous factor for prognosis in the subgroup of EGFR mutation in patients with early and locally advanced-stage lung adenocarcinoma. What's more, this study may provide the theoretical possibility to screen optimal population for a combination therapy with anti-VEGF and anti-IGFR1 in patients with early and locally advanced-stage lung adenocarcinoma.PMID:37702808 | DOI:10.1007/s00432-023-05371-0
Source: Clinical Lung Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Wenting Liu Junling Xia Qingwu Du Jingya Wang Ting Mei Tingting Qin Source Type: research

m < sup > 6 < /sup > A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis
Adv Sci (Weinh). 2023 May 12:e2206744. doi: 10.1002/advs.202206744. Online ahead of print.ABSTRACTThe importance of mRNA N6-methyladenosine (m6 A) modification during tumor metastasis is controversial as it plays distinct roles in different biological contexts. Moreover, how cancer cell plasticity is shaped by m6 A modification is interesting but remains uncharacterized. Here, this work shows that m6 A reader insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is remarkably upregulated in metastatic lung adenocarcinoma (LUAD) and indicates worse prognosis of patients. Interestingly, IGF2BP3 induces partial epithe...
Source: Cancer Control - May 12, 2023 Category: Cancer & Oncology Authors: Xia Yang Qiaorui Bai Weizhong Chen Jiaer Liang Fang Wang Weiqi Gu Lei Liu Quanfeng Li Zishuo Chen Anni Zhou Jianting Long Han Tian Jueheng Wu Xiaofan Ding Ningning Zhou Mengfeng Li Yi Yang Junchao Cai Source Type: research

Diabetes Mellitus-Mediated MALAT1 Expression Induces Glioblastoma Aggressiveness
CONCLUSION: Our findings suggest that one of the mechanisms of the facilitating effect of DM on GB tumor aggressiveness is via MALAT1 expression.PMID:37144653 | DOI:10.5137/1019-5149.JTN.41845-22.2
Source: Turkish Neurosurgery - May 5, 2023 Category: Neurosurgery Authors: Aysen Akkurt Kocaeli Secil Ak Aksoy Melis Ercelik Gulcin Tezcan Cagla Tekin Hasan Kocaeli Ahmet Bekar Mevlut Ozgur Taskapilioglu Sahsine Tolunay Berrin Tunca Source Type: research

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