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Cognitive improvement following ischemia/reperfusion injury induced by voluntary running ‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition.
Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. Int J Mol Med. 2018 Feb 12;: Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Abstract Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be as...
Source: International Journal of Molecular Medicine - February 12, 2018 Category: Molecular Biology Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Tags: Int J Mol Med Source Type: research

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients
ConclusionIn this study, we systematically explored the T-cell exhaustion trajectory in COAD and developed a TES model to assess prognosis and provide guidelines for the treatment decision. This discovery gave rise to a fresh concept for novel therapeutic procedures for the clinical treatment of COAD.
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research