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EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells.
CONCLUSION: EGF could trigger resistance to RET inhibition in CCDC6-RET lung cancer cells, and endothelial cells may confer resistance to RET inhibitors by EGF. E7080 and other RET inhibitors may provide therapeutic benefits in the treatment of RET-positive lung cancer patients. PMID: 27873490 [PubMed - in process]
Source: Yonsei Medical Journal - November 24, 2016 Category: Universities & Medical Training Authors: Chang H, Sung JH, Moon SU, Kim HS, Kim JW, Lee JS Tags: Yonsei Med J Source Type: research

Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells.
Authors: Du C, Wang X, Zhang J, Liu X, Zhu J, Liu Y Abstract Paxillin (PXN) encodes a 68-kDa focal adhesion-associated protein and plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the relationship between PXN and clinicopathological factors in colorectal cancer, the role of PXN in cetuximab resistance, and whether knockdown of PXN expression could improve the sensitivity to cetuximab in colorectal cancer cells. In the present study, immunohistochemical staining in 148 colorectal carcinoma and 126 nor...
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research