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Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model
CONCLUSION: Our experimental data show that pretreated groups in different doses (nano BBR 100, 75, 50 mg/kg, and BBR 100 mg/kg) successfully showed decreased levels of the inflammatory factors in cerebral ischemia compared with the stroke group and pretreated group with nano BBR in the dose of 25 mg/kg. Nano BBR formulation with a lower dose can be a better candidate than conventional BBR formulation to reduce oxidative and inflammatory factors in cerebral ischemia. Therefore, BBR-loaded micelle formulation could be a promising protective agent on cerebral ischemia.PMID:34600570 | PMC:PMC8487542 | DOI:10.1186/s40360-021-00525-7
Source: BMC Pharmacology and Toxicology - October 3, 2021 Category: Drugs & Pharmacology Authors: Roza Azadi Seyyedeh Elaheh Mousavi Negar Motakef Kazemi Hasan Yousefi-Manesh Seyed Mahdi Rezayat Mahmoud Reza Jaafari Source Type: research

Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats
J Environ Pathol Toxicol Oncol. 2021;40(4):11-19. doi: 10.1615/JEnvironPatholToxicolOncol.2021038860.ABSTRACTCerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species production followed by oxidative stress, inflammation of neurons, and death of brain cells. The current work aims to evaluate the effect of troxerutin (TXN) on cerebral injury stimulated by I/R-induced ischemic stroke and examines the mechanistic effect of TXN on neuroinflammation i...
Source: Journal of Environmental Pathology, Toxicology and Oncology - December 22, 2021 Category: Environmental Health Authors: Chao Gao Yunfei Song Taotao Dou Shuai Jiang Haoze Wu Vidya Devanathadesikan Seshadri Vishnu Priya Veeraraghavan Pengfei Hou Source Type: research

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