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The interaction between intestinal microenvironment and stroke
CONCLUSION: The structure and function of the intestinal environment can influence neurological function and cerebral ischemic outcome. Improving the intestinal microenvironment by targeting the gut microbiota may be a new direction in treating stroke.PMID:37309254 | DOI:10.1111/cns.14275
Source: CNS Neuroscience and Therapeutics - June 13, 2023 Category: Neuroscience Authors: Linna Zhao Jie Xiao Songlin Li Yuying Guo Rong Fu Shengyu Hua Yuzheng Du Shixin Xu Source Type: research

Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis
CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.PMID:35322553 | DOI:10.1111/cns.13829
Source: CNS Neuroscience and Therapeutics - March 24, 2022 Category: Neuroscience Authors: Guangwen Li Xiaoqing Ma Haiping Zhao Junfen Fan Tianwei Liu Yumin Luo Yunliang Guo Source Type: research

Inhibition of activator protein 1 attenuates neuroinflammation and brain injury after experimental intracerebral hemorrhage.
CONCLUSIONS: Inhibition of AP-1 curbs neuroinflammation and reduces brain injury following ICH. PMID: 31392841 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - August 7, 2019 Category: Neuroscience Authors: Wei CJ, Li YL, Zhu ZL, Jia DM, Fan ML, Li T, Wang XJ, Li ZG, Ma HS Tags: CNS Neurosci Ther Source Type: research

Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer.
CONCLUSION: This study shows that HBOT preconditioning stands as a robust prophylactic treatment for sequestration of inflammation inherent in stroke and TBI, possibly facilitating the transfer of resilient mitochondria from astrocytes to inflammation-susceptible neuronal cells in mitigating cell death. PMID: 30972972 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 10, 2019 Category: Neuroscience Authors: Lippert T, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Peroxisome Proliferator-activated Receptor-γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats.
CONCLUSIONS: Long-term treatment of pioglitazone has beneficial effect on hypertension-induced WML and cognition decline, which may partly through its effect on attenuation of arteriolar remodeling, endothelial activation, and brain inflammation. PMID: 25611692 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 22, 2015 Category: Neuroscience Authors: Lan LF, Zheng L, Yang X, Ji XT, Fan YH, Zeng JS Tags: CNS Neurosci Ther Source Type: research

Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion-Induced Neural Injury in Mice.
CONCLUSIONS: Our findings reveal that Kir6.1 knockdown exacerbates cerebral I/R-induced brain damages via increasing ER stress and inflammatory response, indicating that Kir6.1-containing K-ATP channels may be a potential therapeutic target for stroke. PMID: 23663330 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 11, 2013 Category: Neuroscience Authors: Dong YF, Wang LX, Huang X, Cao WJ, Lu M, Ding JH, Sun XL, Hu G Tags: CNS Neurosci Ther Source Type: research

The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.
CONCLUSIONS: PDCD5-induced apoptosis and over-expression of PDCD5 are harmful to the ischemic neurons in vivo. Meanwhile, the inhibition of PDCD5 may be protective via reducing the apoptotic-related protein such as p53, Bax, and caspase-3. This observation may have potential for the treatment of ischemic cerebral stroke. PMID: 23638963 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen YY, Han JY, Zhang JH, Zhou CM Tags: CNS Neurosci Ther Source Type: research