Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion-Induced Neural Injury in Mice.

CONCLUSIONS: Our findings reveal that Kir6.1 knockdown exacerbates cerebral I/R-induced brain damages via increasing ER stress and inflammatory response, indicating that Kir6.1-containing K-ATP channels may be a potential therapeutic target for stroke. PMID: 23663330 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23663330?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - May 11, 2013 Category: Neuroscience Authors: Dong YF, Wang LX, Huang X, Cao WJ, Lu M, Ding JH, Sun XL, Hu G Tags: CNS Neurosci Ther Source Type: research