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Postacute Stromal Cell-Derived Factor-1{alpha} Expression Promotes Neurovascular Recovery in Ischemic Mice Basic Sciences
Conclusions— SDF-1α promoted neurogenesis and angiogenesis during the postacute phase of ischemia without eliciting an inflammatory response. AAV-SDF-1α expression represents a promising avenue for ischemic stroke therapy with a wider treatment window.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Li, Y., Huang, J., He, X., Tang, G., Tang, Y.-H., Liu, Y., Lin, X., Lu, Y., Yang, G.-Y., Wang, Y. Tags: Angiogenesis, Animal models of human disease Basic Sciences Source Type: research

Deferoxamine Attenuates White Matter Injury in a Piglet Intracerebral Hemorrhage Model Brief Reports
Conclusions— Deferoxamine reduces white matter edema, tumor necrosis factor α, and receptor-interacting protein kinase 1 levels after ICH in piglets, suggesting deferoxamine is a potential effective therapeutic agent for patients with ICH.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Xie, Q., Gu, Y., Hua, Y., Liu, W., Keep, R. F., Xi, G. Tags: Acute Cerebral Hemorrhage Brief Reports Source Type: research

Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia Basic Sciences
Conclusions— Treg treatment did not exacerbate poststroke immunosuppression. On the contrary, Treg-treated animals displayed improved immune status after focal cerebral ischemia.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Li, P., Mao, L., Zhou, G., Leak, R. K., Sun, B.-L., Chen, J., Hu, X. Tags: Basic Sciences Source Type: research

MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation Basic Sciences
Conclusions— MiR-424 overexpression lessened the ischemic brain injury through suppressing microglia activation by translational depression of key activators of G1/S transition, suggesting a novel miR-based intervention strategy for stroke.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Zhao, H., Wang, J., Gao, L., Wang, R., Liu, X., Gao, Z., Tao, Z., Xu, C., Song, J., Ji, X., Luo, Y. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research

Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation Basic Sciences
Conclusions— Loss of Hcrt neurons in AT mice resulted in worsened stroke outcomes, which were reversed by administration of exogenous Hcrt-1. The mechanism underlying Hcrt-mediated neuroprotection includes attenuation of inflammatory responses after ischemic insult.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Xiong, X., White, R. E., Xu, L., Yang, L., Sun, X., Zou, B., Pascual, C., Sakurai, T., Giffard, R. G., Xie, X. Tags: Ischemic biology - basic studies, Behavioral Changes and Stroke, Neuroprotectors Basic Sciences Source Type: research

Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage Basic Sciences
Conclusions— Intraventricular transplantation of umbilical cord blood-derived mesenchymal stem cells significantly attenuated the posthemorrhagic hydrocephalus and brain injury after IVH. This neuroprotective mechanism appears to be mediated by the anti-inflammatory effects of these cells.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Ahn, S. Y., Chang, Y. S., Sung, D. K., Sung, S. I., Yoo, H. S., Lee, J. H., Oh, W. I., Park, W. S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Basic Sciences Source Type: research

CXCR4 Antagonist AMD3100 Protects Blood-Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice Original Contributions
Conclusions— CXCR4 antagonist AMD3100 significantly suppressed inflammatory response and reduced blood–brain barrier disruption after MCAO. AMD3100 attenuated ischemia-induced acute inflammation by suppressing leukocyte migration and infiltration, in addition to reducing proinflammatory cytokine expression in the ischemic region.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Huang, J., Li, Y., Tang, Y., Tang, G., Yang, G.-Y., Wang, Y. Tags: Animal models of human disease, Arterial thrombosis, Acute Cerebral Infarction, Behavioral Changes and Stroke, Brain Circulation and Metabolism, Other Stroke Treatment - Medical, Other Research Original Contributions Source Type: research

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