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Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes
This study suggests that endothelial-specific ATX leads to increased LPA in the brain vasculature following ischemic-reperfusion and ultimately disrupts vascular permeability, resulting in adverse stroke outcomes.PMID:36766854 | DOI:10.3390/cells12030511
Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Susmita Bhattarai Utsab Subedi Shrivats Manikandan Sudha Sharma Papori Sharma Chloe Miller Md Shenuarin Bhuiyan Srivatsan Kidambi Vassilis Aidinis Hong Sun Sumitra Miriyala Manikandan Panchatcharam Source Type: research

Net benefit of diagnostic tests for multistate diseases: an indicator variables approach
J Biopharm Stat. 2023 Jan 29:1-28. doi: 10.1080/10543406.2023.2169928. Online ahead of print.ABSTRACTA limitation of the common measures of diagnostic test performance, such as sensitivity and specificity, is that they do not consider the relative importance of false negative and false positive test results, which are likely to have different clinical consequences. Therefore, the use of classification or prediction measures alone to compare diagnostic tests or biomarkers can be inconclusive for clinicians. Comparing tests on net benefit can be more conclusive because clinical consequences of misdiagnoses are considered. Th...
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Hani Samawi Ferdous Ahmed Gene Pennello Jingjing Yin Source Type: research

Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts Epidemiology
Conclusions Off-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Zhou, Y., Li, W., Herath, C., Xia, J., Hu, B., Song, F., Cao, S., Lu, Z. Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research