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Cancer: Squamous Cell Carcinoma
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Spontaneous tumor lysis syndrome in squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Sep 28;34(1):128-130. doi: 10.1080/08998280.2020.1818911.ABSTRACTTumor lysis syndrome (TLS) is an oncologic emergency, more commonly occurring in patients with hematologic malignancies receiving cancer-directed therapy due to massive cellular breakdown. Spontaneous TLS is rare and occurs in the absence of cancer-directed therapy. Herein, we present a case of spontaneous TLS associated with squamous cell carcinoma.PMID:33456173 | PMC:PMC7785206 | DOI:10.1080/08998280.2020.1818911
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Mohammad Ammad Ud Din Syed Ather Hussain Leela Krishna Teja Boppana Dharmini Manogna Farhan Imran Source Type: research
Dermatomyositis, pembrolizumab, and squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Aug 27;34(1):120-121. doi: 10.1080/08998280.2020.1811189.ABSTRACTCancer immunotherapy has impacted the treatment of numerous tumor types, including skin, lung, and colon cancers. Immune checkpoint inhibitors (ICI) activate the immune system to attack cancer cells, but this mechanism can also impact healthy cells. Dermatomyositis, an autoimmune syndrome affecting multiple organ systems, is often associated with cancer as a paraneoplastic syndrome, but this syndrome can also be induced by ICI. Here, we describe a case of dermatomyositis in a patient receiving pembrolizumab for treatment of squ...
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Claire J Wiggins Susan Y Chon Source Type: research
Clinical efficacy of anlotinib plus S-1 as a second-line therapy for recurrent or metastatic esophageal squamous cell carcinoma
The objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and adverse effects were evaluated for all the patients.OBJECTIVE: No complete remission (CR) was observed in the 26 patients. Partial remission (PR) was achieved in 6 cases, stable disease (SD) in 12 cases, and progressive disease (PD) occurred in 8 cases, with an ORR of 23.1% and a DCR of 69.2% in these patients. The median PFS was 4.5 months (95%CI: 2.7-6.4 months). Univariate analysis showed that the patients with moderate or high tumor differentiation had significantly longer PFS than those with low tumor differentiation (6....
Source: Journal of Southern Medical University - February 24, 2021 Category: Universities & Medical Training Authors: W Sun X Zou W Zhang S Hu K Ge Source Type: research
Hiatal hernia repair and magnetic sphincter augmentation to treat laryngopharyngeal reflux aiding the prevention of recurrent laryngeal cancer
We present a patient with a squamous cell cancer of the larynx who was diagnosed with gastroesophageal reflux disease (GERD) and found to have LPR. The cancer was treated locally and GERD was eradicated with magnetic sphincter augmentation. After 15 months of follow-up, there was no residual cancer. This case highlights the role that untreated LPR may play in patients' risk of developing laryngeal cancer.PMID:33456181 | PMC:PMC7785177 | DOI:10.1080/08998280.2020.1818167
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Madeline Smoot Marc A Ward Lindsey Arviso Christine E Sanchez Steven G Leeds Source Type: research
A perianal subcutaneous metastasis as the presenting sign for lung cancer
We report a case of a 77-year-old white man who presented with a 9-day history of a painful, rapidly growing mass on his left buttock in the gluteal cleft. The deep dermal location of the neoplasm and the lack of epidermal involvement led to suspicion of a metastatic carcinoma. Imaging showed a lung lesion suspected to be a primary malignancy with distant liver and gastric fundus metastases. Lung pathology showed primarily adenocarcinoma with squamous differentiation, whereas the skin biopsy showed poorly differentiated squamous cell carcinoma. Clinically, we concluded the skin carcinoma was a metastasis of a primary lung ...
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Aaminah Azhar Elizabeth Wilder Source Type: research
Spontaneous tumor lysis syndrome in squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Sep 28;34(1):128-130. doi: 10.1080/08998280.2020.1818911.ABSTRACTTumor lysis syndrome (TLS) is an oncologic emergency, more commonly occurring in patients with hematologic malignancies receiving cancer-directed therapy due to massive cellular breakdown. Spontaneous TLS is rare and occurs in the absence of cancer-directed therapy. Herein, we present a case of spontaneous TLS associated with squamous cell carcinoma.PMID:33456173 | PMC:PMC7785206 | DOI:10.1080/08998280.2020.1818911
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Mohammad Ammad Ud Din Syed Ather Hussain Leela Krishna Teja Boppana Dharmini Manogna Farhan Imran Source Type: research
Dermatomyositis, pembrolizumab, and squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Aug 27;34(1):120-121. doi: 10.1080/08998280.2020.1811189.ABSTRACTCancer immunotherapy has impacted the treatment of numerous tumor types, including skin, lung, and colon cancers. Immune checkpoint inhibitors (ICI) activate the immune system to attack cancer cells, but this mechanism can also impact healthy cells. Dermatomyositis, an autoimmune syndrome affecting multiple organ systems, is often associated with cancer as a paraneoplastic syndrome, but this syndrome can also be induced by ICI. Here, we describe a case of dermatomyositis in a patient receiving pembrolizumab for treatment of squ...
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Claire J Wiggins Susan Y Chon Source Type: research
Clinical efficacy of anlotinib plus S-1 as a second-line therapy for recurrent or metastatic esophageal squamous cell carcinoma
The objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and adverse effects were evaluated for all the patients.OBJECTIVE: No complete remission (CR) was observed in the 26 patients. Partial remission (PR) was achieved in 6 cases, stable disease (SD) in 12 cases, and progressive disease (PD) occurred in 8 cases, with an ORR of 23.1% and a DCR of 69.2% in these patients. The median PFS was 4.5 months (95%CI: 2.7-6.4 months). Univariate analysis showed that the patients with moderate or high tumor differentiation had significantly longer PFS than those with low tumor differentiation (6....
Source: Journal of Southern Medical University - February 24, 2021 Category: Universities & Medical Training Authors: W Sun X Zou W Zhang S Hu K Ge Source Type: research
Hiatal hernia repair and magnetic sphincter augmentation to treat laryngopharyngeal reflux aiding the prevention of recurrent laryngeal cancer
We present a patient with a squamous cell cancer of the larynx who was diagnosed with gastroesophageal reflux disease (GERD) and found to have LPR. The cancer was treated locally and GERD was eradicated with magnetic sphincter augmentation. After 15 months of follow-up, there was no residual cancer. This case highlights the role that untreated LPR may play in patients' risk of developing laryngeal cancer.PMID:33456181 | PMC:PMC7785177 | DOI:10.1080/08998280.2020.1818167
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Madeline Smoot Marc A Ward Lindsey Arviso Christine E Sanchez Steven G Leeds Source Type: research
A perianal subcutaneous metastasis as the presenting sign for lung cancer
We report a case of a 77-year-old white man who presented with a 9-day history of a painful, rapidly growing mass on his left buttock in the gluteal cleft. The deep dermal location of the neoplasm and the lack of epidermal involvement led to suspicion of a metastatic carcinoma. Imaging showed a lung lesion suspected to be a primary malignancy with distant liver and gastric fundus metastases. Lung pathology showed primarily adenocarcinoma with squamous differentiation, whereas the skin biopsy showed poorly differentiated squamous cell carcinoma. Clinically, we concluded the skin carcinoma was a metastasis of a primary lung ...
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Aaminah Azhar Elizabeth Wilder Source Type: research
Spontaneous tumor lysis syndrome in squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Sep 28;34(1):128-130. doi: 10.1080/08998280.2020.1818911.ABSTRACTTumor lysis syndrome (TLS) is an oncologic emergency, more commonly occurring in patients with hematologic malignancies receiving cancer-directed therapy due to massive cellular breakdown. Spontaneous TLS is rare and occurs in the absence of cancer-directed therapy. Herein, we present a case of spontaneous TLS associated with squamous cell carcinoma.PMID:33456173 | PMC:PMC7785206 | DOI:10.1080/08998280.2020.1818911
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Mohammad Ammad Ud Din Syed Ather Hussain Leela Krishna Teja Boppana Dharmini Manogna Farhan Imran Source Type: research
Dermatomyositis, pembrolizumab, and squamous cell carcinoma of the lung
Proc (Bayl Univ Med Cent). 2020 Aug 27;34(1):120-121. doi: 10.1080/08998280.2020.1811189.ABSTRACTCancer immunotherapy has impacted the treatment of numerous tumor types, including skin, lung, and colon cancers. Immune checkpoint inhibitors (ICI) activate the immune system to attack cancer cells, but this mechanism can also impact healthy cells. Dermatomyositis, an autoimmune syndrome affecting multiple organ systems, is often associated with cancer as a paraneoplastic syndrome, but this syndrome can also be induced by ICI. Here, we describe a case of dermatomyositis in a patient receiving pembrolizumab for treatment of squ...
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Claire J Wiggins Susan Y Chon Source Type: research
Clinical efficacy of anlotinib plus S-1 as a second-line therapy for recurrent or metastatic esophageal squamous cell carcinoma
The objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and adverse effects were evaluated for all the patients.OBJECTIVE: No complete remission (CR) was observed in the 26 patients. Partial remission (PR) was achieved in 6 cases, stable disease (SD) in 12 cases, and progressive disease (PD) occurred in 8 cases, with an ORR of 23.1% and a DCR of 69.2% in these patients. The median PFS was 4.5 months (95%CI: 2.7-6.4 months). Univariate analysis showed that the patients with moderate or high tumor differentiation had significantly longer PFS than those with low tumor differentiation (6....
Source: Journal of Southern Medical University - February 24, 2021 Category: Universities & Medical Training Authors: W Sun X Zou W Zhang S Hu K Ge Source Type: research
