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Proteomic Profiling of Chikungunya Virus-Infected Human Muscle Cells: Reveal The Role of Cytoskeleton Network in CHIKV Replication.
Abstract Chikungunya virus (CHIKV) is an arthropod-borne, positive-sense, single-stranded RNA virus belonging to genus Alphavirus and family Togaviridae. The clinical manifestations developed upon CHIKV-infection include fever, myositis, arthralgia and maculopapular rash. Thus, the re-emergence of CHIKV has posed serious health threats worldwide. Due to the fact that myositis is induced upon CHIKV-infection, we sought to understand the dynamic proteomic regulation in SJCRH30, a human rhabdomyosarcoma cell line, to gain insights on CHIKV pathogenesis. Two-dimensional gel electrophoresis (2DE) in combination of matr...
Source: Journal of Proteomics - June 13, 2014 Category: Biochemistry Authors: Issac TH, Lee TE, Chu JJ Tags: J Proteomics Source Type: research

Macropinocytosis Dependent Entry of Chikungunya Virus into Human Muscle Cells
This study shows for the first time, that the infectious entry of CHIKV into human muscle cells is mediated by macropinocytosis. Together, the da ta from this study may pave the way for the development of specific inhibitors that target the entry process of CHIKV into cells.
Source: PLoS Neglected Tropical Diseases - August 25, 2019 Category: Tropical Medicine Authors: Ching Hua, Regina Lee Source Type: research