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Cancer: Skin Cancer
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Melanocytic Nevi of Special Sites
Abstract: Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Now, additional anatomical sites with known site-related atypia include the ear, conjunctivae,...
Source: The American Journal of Dermatopathology - November 22, 2016 Category: Pathology Tags: CME Article Source Type: research
Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer
Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma.
Summary: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions. Proper management includes distinguishing between high-risk and low-risk lesions and determining treatment...
Source: Plastic and Reconstructive Surgery - December 29, 2016 Category: Cosmetic Surgery Tags: MOC-CME Source Type: research
The role of imaging in the management of patients with nonmelanoma skin cancer
While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer.
Source: Journal of the American Academy of Dermatology - March 20, 2017 Category: Dermatology Authors: Deborah MacFarlane, Komal Shah, Ashley Wysong, Ximena Wortsman, Tatyana R. Humphreys Tags: Continuing medical education Source Type: research
The status of dermoscopy in Germany – results of the cross‐sectional Pan‐Euro‐Dermoscopy Study
ConclusionsThe findings presented herein ought to be integrated into future residency and continuing medical education programs with the challenge to improve dermato‐oncological care and to expand the diagnostic spectrum of dermoscopy to include inflammatory skin diseases.
Source: JDDG - January 31, 2018 Category: Dermatology Authors: Andreas Blum, J ürgen Kreusch, Wilhelm Stolz, Giuseppe Argenziano, Ana‐Maria Forsea, Veronique D. Marmol, Iris Zalaudek, Hans P. Soyer, Holger A. Haenssle Tags: Original Article Source Type: research
Reply to: “Cutaneous squamous cell carcinoma progression during imiquimod treatment”
To the Editor: We appreciate the observation made by Dika et al about cutaneous squamous cell carcinoma (cSCC) progression during imiquimod treatment.1 These cases emphasize what we describe in part II of our continuing medical education (CME) article–that topical chemotherapy agents should be limited to the treatment of actinic keratoses and squamous cel l carcinoma in situ and are only Food and Drug Administration–approved for use on actinic keratoses.2 As stated in the CME article, our preferred treatment choice for widespread actinic damage is topical 5-fluorouracil, as imiquimod is not practical for application ...
Source: Journal of the American Academy of Dermatology - March 26, 2018 Category: Dermatology Authors: Syril Keena T. Que, Fiona O. Zwald, Chrysalyne D. Schmults Tags: JAAD online Source Type: research
Current controversies in early-stage melanoma
There are a number of controversies and uncertainties relating to the management and surveillance of patients with early-stage, localized (ie, stage 0, I, and II) cutaneous melanoma. While tumor stage is a critical predictor of clinical outcome and guides treatment, accurate determination of stage may be affected by the biopsy technique used and the method of sectioning before histologic review. A new molecular prognostic test is available but has not been formally incorporated into staging or treatment guidelines.
Source: Journal of the American Academy of Dermatology - December 13, 2018 Category: Dermatology Authors: Marki E. Klapperich, Glen M. Bowen, Douglas Grossman Tags: Continuing medical education Source Type: research
JAAD Game Changers: Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study
Source: Journal of the American Academy of Dermatology - October 30, 2018 Category: Dermatology Authors: Eden Lake Tags: Continuing medical education Source Type: research
Dermatologic care for lesbian, gay, bisexual, and transgender persons
Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM.
Source: Journal of the American Academy of Dermatology - February 9, 2019 Category: Dermatology Authors: Howa Yeung, Kevin M. Luk, Suephy C. Chen, Brian A. Ginsberg, Kenneth A. Katz Tags: Continuing medical education Source Type: research
Technological advances for the detection of melanoma: Part II. Advances in molecular techniques
The growth of molecular technologies analyzing skin cells and inherited genetic variations has the potential to address current gaps in both diagnostic accuracy and prognostication in melanoma patients or in individuals at risk for developing melanoma. In part II of this continuing medical education article, novel molecular technologies are reviewed. These have been developed as adjunct tools for melanoma management and include the Pigmented Lesion Assay (PLA), myPath Melanoma, and DecisionDx-Melanoma tests, and genetic testing in patients with a strong familial melanoma history.
Source: Journal of the American Academy of Dermatology - April 28, 2020 Category: Dermatology Authors: Lauren Fried, Andrea Tan, Shirin Bajaj, Tracey N. Liebman, David Polsky, Jennifer A. Stein Source Type: research
Reflectance confocal microscopy. Part II. Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathological correlates of key confocal criteria, and diagnostic algorithms
Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers —melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions—melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia.
Source: Journal of the American Academy of Dermatology - June 16, 2020 Category: Dermatology Authors: Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope Source Type: research
Technological advances for the detection of melanoma
Managing the balance between accurately identifying early stage melanomas while avoiding obtaining biopsy specimens of benign lesions (ie, overbiopsy) is the major challenge of melanoma detection. Decision making can be especially difficult in patients with extensive atypical nevi. Recognizing that the primary screening modality for melanoma is subjective examination, studies have shown a tendency toward overbiopsy. Even low-risk routine surgical procedures are associated with morbidity, mounting health care costs, and patient anxiety.
Source: Journal of the American Academy of Dermatology - April 25, 2020 Category: Dermatology Authors: Lauren Fried, Andrea Tan, Shirin Bajaj, Tracey N. Liebman, David Polsky, Jennifer A. Stein Tags: Continuing medical education Source Type: research
New Developments in the Management of Cutaneous Squamous Cell Carcinoma
Learning Objectives:
After studying this article, the participant should be able to: 1. List important prognostic features that affect cutaneous squamous cell carcinoma risk. 2. Summarize the changes to the AJCC Cancer Staging Manual, Eighth Edition, staging system for cutaneous squamous cell carcinoma. 3. Evaluate the draining nodal basin with appropriate imaging modalities. 4. Recommend adjuvant radiation therapy in the correct clinical setting for high-risk tumors. 5. Recognize the currently available treatments for advanced cutaneous squamous cell carcinoma.
Summary:
This continuing medical education article...
Source: Plastic and Reconstructive Surgery - March 1, 2021 Category: Cosmetic Surgery Tags: CME Source Type: research
The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?
Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma ...
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Authors: Kelly M. Wilmas, Wesley B. Garner, Matthew T. Ballo, Susan L. McGovern, Deborah F. MacFarlane Source Type: research
Melanoma: An Update on Systemic Therapies
Despite advances in early detection as described in Part 1, melanoma continues to be a large contributor to cutaneous cancer-related mortality. In a subset of patients with unresectable or metastatic disease, surgical clearance is often not possible, and therefore, systemic and local therapies are considered. The second article in this continuing medical education series provides dermatologists with an up-to-date working knowledge of the treatment options that may be prescribed by oncologists for patients with unresectable stage III, stage IV, and recurrent melanoma.
Source: Journal of the American Academy of Dermatology - December 12, 2021 Category: Dermatology Authors: Lauren Skudalski, Reid Waldman, Philip E. Kerr, Jane M. Grant-Kels Source Type: research
