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Extracorporeal life support allows lung transplant in anti-MDA5+ rapidly progressive interstitial lung disease
Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5) dermatomyositis (DM) is a rare subtype of idiopathic inflammatory myopathy, associated with severe interstitial lung disease (ILD) [1]. A subset of anti-MDA5 DM patients with rapidly progressive ILD (RP-ILD) have a very poor prognosis, with reported mortality rates reaching 80–84% [1, 2]. In this clinical setting, the use of extracorporeal life support (ECLS) is questionable, as reported in several studies that emphasise the futility of a bridge-to-recovery strategy [2, 3]. In this respect, emergency lung transplantation of previously unlisted patie...
Source: European Respiratory Journal - May 26, 2022 Category: Respiratory Medicine Authors: Bay, P., Pineton de Chambrun, M., Roux, A., Bunel, V., Combes, A., Israël-Biet, D., Zuber, B., Nunes, H., Allenbach, Y., Uzunhan, Y. Tags: Original Articles: Research letters Source Type: research

Inflammatory myopathies after allogeneic stem cell transplantation
Discussion: Among recipients of allo ‐SCT, weakness is common, and the incidence of IM is increased. Histopathological diagnoses are varied, and we report findings of necrotizing myopathy and anti‐MDA5‐associated DM.Muscle Nerve, 2018
Source: Muscle and Nerve - November 20, 2018 Category: Internal Medicine Authors: Julia New ‐Tolley, Caroline Smith, Barbara Koszyca, Sophia Otto, Adam Maundrell, Peter Bardy, Devendra Hiwase, Agnes S. M. Yong, Ian Lewis, Vidya Limaye Tags: Clinical Research Source Type: research