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NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Elevated Cardiovascular Disease Risk in Patients With Chronic Myelogenous Leukemia Seen in Community-based Oncology Practices in the United States
Conclusion The increased risk of CVD observed in this real-world analysis of CML patients underscores the importance of current NCCN® recommendations to consider CV risk when selecting TKIs. Teaser Guidelines recommend that comorbidities, including CVD, be considered when selecting TKIs for the treatment of CML. An increased risk of CVD and its risk factors in CML patients treated by community-based US oncologists was identified in a real-world analysis of an EMR database (N=1,639). These results underscore the importance of current NCCN® recommendations to consider CV risk when selecting TKIs.
Source: Clinical Lymphoma Myeloma and Leukemia - June 20, 2017 Category: Cancer & Oncology Source Type: research

Influence of Conventional Cardiovascular Risk Factors and Lifestyle Characteristics on Cardiovascular Disease After Hematopoietic Cell Transplantation Health Services and Outcomes
Conclusion Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT.
Source: Journal of Clinical Oncology - January 17, 2014 Category: Cancer & Oncology Authors: Chow, Baker, Lee, Flowers, Cushing-Haugen, Inamoto, Khera, Leisenring, Syrjala, Martin Tags: Leukemia, Lymphoma, Myeloma, Outcomes Research Health Services and Outcomes Source Type: research