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COVID-19 mRNA Vaccination Appears Safe in Pediatric Patients With A Hypersensitivity Reaction To PEGylated Escherichia Coli L-Asparaginase
L-Asparaginase is an established component of acute leukemia therapy. PEG-asparaginase (PEGAsp), Escheria coli L-asparaginase linked to polyethylene glycol (PEG), is a common first-line formulation. However, PEGAsp hypersensitivity occurs in 10-15% of patients, with the PEG component most commonly suggested [PCA1] antigenic culprit. Because mRNA COVID-19 vaccines contain PEG, albeit of a different molecular weight, administration safety in patients with prior PEGAsp hypersensitivity has been questioned.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Nicole Wolfset, Charles Phillips, Madison Stein, Susan Rheingold, Jennifer Heimall, Caitlin Elgarten Source Type: research

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
CONCLUSION Pediatric patients with SARS–CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19.FUNDING Financial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex’s Lemonade Stand Foundation for Childhood Cancer; Children’s Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Am...
Source: Journal of Clinical Investigation - October 6, 2020 Category: Biomedical Science Authors: Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T Source Type: research