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Unraveling crime scenes strand by strand: the forensic odyssey of Bruce Budowle
Biotechniques. 2023 Aug 25. doi: 10.2144/btn-2023-0069. Online ahead of print.ABSTRACTBruce Budowle speaks to Ashling Cannon, Journal Development Editor for BioTechniques, about advancements & challenges in forensic science. Budowle completed his doctorate in genetics at Virginia Tech (VA, USA) formally known as Virginia Polytechnic Institute and State University. He then went on to complete a postdoctoral fellowship at the University of Alabama at Birmingham (AL, USA) to study genetic risk factors for acute lymphocytic leukemia, diabetes and melanoma. Budowle was early in his career and hadn't spent much time in foren...
Source: BioTechniques - August 25, 2023 Category: Biotechnology Authors: Bruce Budowle Source Type: research

An interplay of Progesterone, Leukemia Inhibitor Factor and Interleukin-6 in the window of implantation; Impact on fertility
CONCLUSION: Elevated levels of Pt were found to increase the production of LIF in fertile females. However, infertile females with PCOs and Uex-IF exhibited deficient levels of Pt, supporting its role as a biomarker for successful implantation in infertile women. These females showed decreased levels of gonadotropins as well as reduced LH/FSH ratio and diminished secretion of receptivity marker LIF, in addition to reduced Pt secretion. This suggests that reduced gonadotropin levels contribute to a lower LH/FSH ratio, resulting in decreased Pt secretion and ultimately leading to low levels of LIF, thereby causing impaired i...
Source: Cytokine - August 16, 2023 Category: Molecular Biology Authors: Rabiya Ali Taseer Ahmed Khan Hina Gul Rehana Rehman Source Type: research

Zeta-associated protein 70 expression in chronic lymphocytic leukemia: Relevance in Indian context
CONCLUSION: We found a lower prevalence rate of ZAP-70 (2/29, 6.89%) with no association with any of the conventional poor prognostic factors. A large number of our CLL patients fall into the good prognostic group (22/29, ZAP 70-/CD38-) with a least number in the poor prognostic group (2/29, ZAP-70 + CD38+). Also, no association was found between ZAP-70 and CD38. The findings of the present study suggest that the majority of CLL patients in India have a good prognosis, may not require treatment, and have good overall survival. Geographical variations, genetic makeup, and natural history of the CLL could be the cause of suc...
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Richa Gupta Neha Garg Abha Singh Shyam Lata Jain Source Type: research

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