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Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1)
Int J Hematol. 2021 Mar 27. doi: 10.1007/s12185-021-03140-8. Online ahead of print.ABSTRACTTransplant acquired food allergy (TAFA) is a well-known complication following pediatric liver transplantation, but post-cord blood transplantation (post-CBT) TAFA has rarely been reported. Here, we describe a case of new-onset food anaphylaxis after CBT in an adult patient that demonstrates that post-CBT allergen-challenge is not a risk for long-term allergic sensitization even in adult recipients. The patient was a 39-year-old Japanese man with aggressive NK cell leukemia. He had no previous history of allergies. After receiving CB...
Source: International Journal of Hematology - March 27, 2021 Category: Hematology Authors: Ai Kawahara Tsukasa Nakanishi Midori Goto Kenichi Akao Takefumi Katsuragi Junichi Tsukada Source Type: research

All Itching Is Not Benign; A Case of Refractory Hypereosinophilic Syndrome Treated with Off Label CD52 Inhibitor-Alemtuzumab
CONCLUSIONOur patient responded well to alemtuzumab, without any notable side effects. Therapy should be reserved due to early and late adverse affects but this agent has proved to be an effective treatment for HES in terms of both complete hematologic response and duration (Strati, P. et. al Clinical Lymphoma, Myeloma & Leukemia 2012). Moreover resistance is not seen, as patients with relapse were able to achieve a second remission. Data about efficacy and safety in the long-term remains lacking, but for treatment resistant and refractory HES, Alemtuzmab may be a suitable choice.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ansari, R., Osuna Salazar, E. N., Sarhill, N., Garcia, L. E., Hanley, J. Tags: 634. Myeloproliferative Syndromes: Clinical Source Type: research

Diagnosis and management of mastocytosis: an emerging challenge in applied hematology.
Authors: Valent P Abstract Mastocytosis is a unique and rare neoplasm defined by abnormal expansion and accumulation of clonal mast cells (MCs) in one or multiple organ systems. Most adult patients are diagnosed to have systemic mastocytosis (SM). Based on histological findings and disease-related organ damage, SM is classified into indolent SM (ISM), smoldering SM (SSM), SM with an associated hematologic non-MC-lineage disease (SM-AHNMD), aggressive SM (ASM), and MC leukemia (MCL). The clinical picture, course, and prognosis vary profoundly among these patients. Nonetheless, independent of the category of SM, neop...
Source: Hematology ASH Education Program - December 10, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies
Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukocyte antigen (HLA) alleles in patients of European ancestry enrolled on leukemia trials at St. Jude Children’s Research Hospital (n = 541) and the Children’s Oncology Group (n = 1329). We identified a higher incidence of hypersensitivity and anti-asparaginase antibodies in patients with HLA-DRB1*07:01 alleles (P = 7.5 x ...
Source: Blood - August 21, 2014 Category: Hematology Authors: Fernandez, C. A., Smith, C., Yang, W., Date, M., Bashford, D., Larsen, E., Bowman, W. P., Liu, C., Ramsey, L. B., Chang, T., Turner, V., Loh, M. L., Raetz, E. A., Winick, N. J., Hunger, S. P., Carroll, W. L., Onengut-Gumuscu, S., Chen, W.-M., Concannon, P Tags: Pediatric Hematology, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Epidemiology of MPN: What Do We Know?
Abstract The myeloproliferative neoplasms, are characterised by overproduction of myeloid cells. Chronic myeloid leukaemia, polycythaemia vera, essential thrombocythaemia, myelofibrosis and the very rare disorders chronic neutrophilic leukaemia, chronic eosinophilic leukaemia not otherwise specified and mastocytosis are all included in the group. Incidence and prevalence rates reported in the worldwide literature are presented in this review. Survival data on each condition is described. Information on the aetiology of the disorders is discussed including body mass index, diet, smoking and alcohol, allergies, asso...
Source: Current Hematologic Malignancy Reports - August 17, 2014 Category: Hematology Source Type: research

A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia
This study prospectively analyzed the efficacy of very prolonged courses of pegylated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. Patients received 15 PEGasparaginase infusions (2500 IU/m2 every 2 weeks) in intensification after receiving native E coli asparaginase in induction. In case of allergy to or silent inactivation of PEGasparaginase, Erwinia asparaginase (20 000 IU/m2 2-3 times weekly) was given. Eighty-nine patients were enrolled in the PEGasparaginase study. Twenty (22%) of the PEGasparaginase–treated patients developed ...
Source: Blood - March 27, 2014 Category: Hematology Authors: Tong, W. H., Pieters, R., Kaspers, G. J. L., te Loo, D. M. W. M., Bierings, M. B., van den Bos, C., Kollen, W. J. W., Hop, W. C. J., Lanvers-Kaminsky, C., Relling, M. V., Tissing, W. J. E., van der Sluis, I. M. Tags: Pediatric Hematology, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research