• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Molecules, Vol. 28, Pages 2400: Bruton & rsquo;s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials
Molecules, Vol. 28, Pages 2400: Bruton’s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials Molecules doi: 10.3390/molecules28052400 Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak In the last few decades, there has been a growing interest in Bruton’s tyrosine kinase (BTK) and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) signaling pathway and affects B-cell proliferation and differentiation. Evidence demonstrating the expression of BTK on t...
Source: Molecules - March 6, 2023 Category: Chemistry Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak Tags: Review Source Type: research

Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor
Biomed Res Int. 2022 Jul 6;2022:6865472. doi: 10.1155/2022/6865472. eCollection 2022.ABSTRACTBetamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn's disease, skin diseases (such as dermatitis and psoriasis), systemic lupus erythematosus, rheumatic disorders, and leukemia. Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone dipropionate (1) and to carry out the molecular docking and ADME analyses. Biotransformation of 1 was carried out with Launaea capitata (dandy) roots and Musa acu...
Source: Biomed Res - July 22, 2022 Category: Research Authors: Sana Rashid Shazia Anjum Aqeel Ahmad Raziya Nadeem Maqsood Ahmed Syed Adnan Ali Shah Muhammad Abdullah Komal Zia Zaheer Ul-Haq Source Type: research