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Risk of First and Recurrent Stroke in Childhood Cancer Survivors Treated With Cranial and Cervical Radiation Therapy
Conclusion: Cranial irradiation puts childhood cancer survivors at high risk of both first and recurrent stroke. Stroke prevention strategies for these survivors are needed.
Source: International Journal of Radiation Oncology * Biology * Physics - April 24, 2013 Category: Radiology Authors: Sabine Mueller, Katherine Sear, Nancy K. Hills, Nassim Chettout, Shervin Afghani, Erica Gastelum, Daphne Haas-Kogan, Heather J. Fullerton Tags: Pediatric Cancers Source Type: research

Radiation, Atherosclerotic Risk Factors, and Stroke Risk in Survivors of Pediatric Cancer: A Report From the Childhood Cancer Survivor Study
Conclusion: Young adult pediatric cancer survivors have an increased stroke risk that is associated with CRT in a dose-dependent manner. Atherosclerotic risk factors enhanced this risk and should be treated aggressively.
Source: International Journal of Radiation Oncology * Biology * Physics - May 15, 2013 Category: Radiology Authors: Sabine Mueller, Heather J. Fullerton, Kayla Stratton, Wendy Leisenring, Rita E. Weathers, Marilyn Stovall, Gregory T. Armstrong, Robert E. Goldsby, Roger J. Packer, Charles A. Sklar, Daniel C. Bowers, Leslie L. Robison, Kevin R. Krull Tags: Pediatric Cancers Source Type: research

Risk of symptomatic stroke after radiotherapy for childhood cancer: a long-term follow-up cohort analysis
Stroke is one of the most serious late effects that occur in childhood cancer survivors. We determined the cumulative incidence of clinically validated symptomatic stroke, and analyzed dose-effect relationships for cranial radiotherapy (CRT) and supradiaphragmatic radiotherapy (SDRT). One in 8 survivors irradiated at both locations will have experienced a symptomatic stroke at an attained age of 45 years. Multivariate Cox models showed that CRT and SDRT increase the risk of stroke in a dose-dependent manner.
Source: International Journal of Radiation Oncology * Biology * Physics - April 6, 2016 Category: Radiology Authors: Irma W.E.M. van Dijk, Helena J.H. van der Pal, Rob M. van Os, Yvo B.W.E.M. Roos, Elske Sieswerda, Elvira C. van Dalen, Cécile M. Ronckers, Foppe Oldenburger, Flora E. van Leeuwen, Huib N. Caron, Caro C.E. Koning, Leontien C.M. Kremer Tags: Clinical Investigation Source Type: research

Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis
Long-term childhood cancer survivors are at high risk of late adverse effects, including stroke. We aimed to determine the cumulative incidence of clinically validated symptomatic stroke (transient ischemic attack [TIA], cerebral infarction, and intracerebral hemorrhage [ICH]) and to quantify dose-effect relationships for cranial radiation therapy (CRT) and supradiaphragmatic radiation therapy (SDRT).
Source: International Journal of Radiation Oncology * Biology * Physics - April 6, 2016 Category: Radiology Authors: Irma W.E.M. van Dijk, Helena J.H. van der Pal, Rob M. van Os, Yvo B.W.E.M. Roos, Elske Sieswerda, Elvira C. van Dalen, Cécile M. Ronckers, Foppe Oldenburger, Flora E. van Leeuwen, Huib N. Caron, Caro C.E. Koning, Leontien C.M. Kremer Tags: Clinical Investigation Source Type: research

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology.
CONCLUSIONS: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate- or low-dose exposed groups, with some not altogether consistent evidence suggesting dose response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose response. Nuclear cata...
Source: International Journal of Radiation Biology - January 22, 2021 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Risk of Radiation Vasculopathy and Stroke in Pediatric Patients Treated with Proton Therapy for Brain and Skull Base Tumors
Childhood cancer survivors are at risk of vasculopathy. This review of 651 children treated with proton therapy estimates the rate of serious vasculopathy is 2.6% at 3 years following treatment. Young age and doses ≥54 CGE to the suprasellar region are the dominant risk factors.
Source: International Journal of Radiation Oncology * Biology * Physics - March 29, 2018 Category: Radiology Authors: Matt D. Hall, Julie A. Bradley, Ronny L. Rotondo, Ricardo Hanel, Chetan Shah, Christopher G. Morris, Philipp R. Aldana, Daniel J. Indelicato Tags: Clinical Investigation Source Type: research