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Synthesis of Novel Aryloxyethylamine Derivatives and Evaluation of Their in Vitro and in Vivo Neuroprotective Activities.
Abstract A series of aryloxyacetamine derivatives W1 - W37 were designed, synthesized and evaluated for their biological activity. Their structures were confirmed by 1 H-NMR, 13 C-NMR, and HR-ESI-MS. The preliminary screening of neuroprotection of compounds in vitro was detected by MTT, and the anti-ischaemic activity in vivo was tested using bilateral common carotid artery occlusion in Kunming Mice. Most of these compounds showed potent neuroprotective effects against the glutamate-induced cell death in differentiated rat pheochromocytoma cells (PC12 cells), especially for W1 , W7 , W16 , W26 , W28 , W29 and W30 ...
Source: Chemistry and Biodiversity - June 23, 2020 Category: Biochemistry Authors: Zhong Y, Gao Y, Xu Y, Qi C, Wu B Tags: Chem Biodivers Source Type: research

MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF- κB signaling by targeting TLR8 in PC12 cells.
MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-κB signaling by targeting TLR8 in PC12 cells. Biosci Biotechnol Biochem. 2020 Aug 20;:1-8 Authors: Lu YY, Ma XJ, Yang YN Abstract This work aimed to assess the role of TLR8 in cerebral I/R injury and its in-depth pathogenesis. Bioinformatics analysis indicated that TLR8 was up-regulated in patients with ischemic stroke than that in healthy control, and miR-18a-5p was the upstream regulatory of TLR8. Then, the rat pheochromocytoma PC12 cells were exposed in oxygen-glucose-deprivation/reoxyg...
Source: Bioscience, Biotechnology, and Biochemistry - August 19, 2020 Category: Biochemistry Authors: Lu YY, Ma XJ, Yang YN Tags: Biosci Biotechnol Biochem Source Type: research