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Effect and mechanism analysis of siRNA in inhibiting VEGF and its anti-angiogenesis effects in human osteosarcoma bearing rats.
CONCLUSIONS: The growth of tumor tissue in osteosarcoma bearing rats is inhibited in Ad-VEGF-siRNA group, Ad-VEGF-siRNA + neoadjuvant chemotherapy group and Ad-VEGF-siRNA + anti-angiogenesis chemotherapy group. The effect in Ad-VEGF-siRNA + neoadjuvant chemotherapy is more significant than simple biological therapy or Ad-VEGF-siRNA + anti-angiogenesis chemotherapy. PMID: 26636524 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 6, 2015 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

RLN2 regulates in vitro invasion and viability of osteosarcoma MG-63 cells via S100A4/MMP-9 signal.
CONCLUSIONS: Our results indicate that RLN2 regulats cell migration, invasiveness and proliferation of osteosarcoma cells in vitro, which may be mediated through S100A4/MMP-9 signaling. PMID: 25855929 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reviews - November 20, 2015 Category: Drugs & Pharmacology Authors: Ren XF, Zhao H, Gong XC, Wang LN, Ma JF Tags: Eur Rev Med Pharmacol Sci Source Type: research

Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway.
Abstract Osteosarcoma is the most common primary malignancy of bone and is characterized by a high malignant and metastatic potential. Transforming growth factor alpha (TGF-α) is classified as the EGF (epidermal growth factor)-like family, which is involved in cancer cellular activities such as proliferation, motility, migration, adhesion and invasion abilities. However, the effect of TGF-α on human osteosarcoma is largely unknown. We found that TGF-α increased the cell migration and expression of intercellular adhesion molecule-1 (ICAM-1) in human osteosarcoma cells. Transfection of cells with ICAM-1 siRNA red...
Source: Biochemical Pharmacology - March 28, 2014 Category: Drugs & Pharmacology Authors: Hou CH, Lin FL, Tong KB, Hou SM, Liu JF Tags: Biochem Pharmacol Source Type: research

G protein‐gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThese results demonstrate that KIR3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal KIR3.1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: RESEARCH PAPER Source Type: research

G protein‐gated inwardly rectifying potassium (GIRK) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThe results demonstrated that GIRK1 channels play a primary role in the antinociceptive effects of oxycodone, but not morphine, at supraspinal sites, and suggested that supraspinal GIRK1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - October 7, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: Research Paper Source Type: research

SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
In this study, we assessed the antitumor activity of melatonin against human osteosarcoma cells (9607 cell line) and explored the role of SIRT1 in the activity of melatonin. melatonin treatment resulted in strong antitumor activity, as evidenced not only by reductions in tumor cell vitality, adhesion ability, migration ability and glutathione (GSH) levels but also by increases in the apoptotic index and reactive oxygen species. Additionally, melatonin treatment down-regulated SIRT1 and up-regulated acetylated-p53. Sirtinol (a known SIRT1 inhibitor) and SIRT1 siRNA further enhanced the antitumor activity of melatonin, while...
Source: European Journal of Pharmacology - May 29, 2013 Category: Drugs & Pharmacology Authors: Cheng Y, Cai L, Jiang P, Wang J, Gao C, Feng H, Wang C, Pan H, Yang Y Tags: Eur J Pharmacol Source Type: research

Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma.
Abstract Osteosarcoma is characterized by a high malignant and metastatic potential. Angiogenesis is essential for the caner metastasis. Interleukin-6 (IL-6) is a multifunctional cytokine that is associated with the disease status and outcomes of cancers. However, the relationship between IL-6 and vascular endothelial growth factor (VEGF) expression in human osteosarcoma is mostly unknown. Here we found that the IL-6 and VEGF expression was correlated with tumor stage and significantly higher than that in normal bone. Incubation of osteosarcoma cells with IL-6 increased VEGF mRNA and protein expression. Pretreatme...
Source: Biochemical Pharmacology - December 5, 2012 Category: Drugs & Pharmacology Authors: Tzeng HE, Tsai CH, Chang ZL, Su CM, Wang SW, Hwang WL, Tang CH Tags: Biochem Pharmacol Source Type: research

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