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Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients
Condition: Head and Neck Squamous Cell Carcinoma Interventions: Drug: Buprenorphine; Drug: Tramadol; Drug: Oxycodone; Radiation: Definitive radiation; Device: Oral Mucositis (OM) Pain App Sponsor: Medical College of Wisconsin Not yet recruiting
Source: ClinicalTrials.gov - February 12, 2021 Category: Research Source Type: clinical trials
Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.
CONCLUSIONS: The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers.
IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for thei...
Source: Journal of the Medical Library Association : JMLA - January 4, 2015 Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research
Search for potential Inducible Nitric Oxide Synthase inhibitors with favorable ADMET profiles for the therapy of Helicobacter pylori infections.
CONCLUSION: The top-ranked compounds from the virtual screening workflow show promising results regarding the iNOS inhibition profile. The results evidenced the importance of the ionic bonding during docking selection, playing a crucial role in binding and positioning during ligand-target selection for iNOS.
PMID: 31721712 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - November 10, 2019 Category: Chemistry Authors: Rodrigues RP, Ardisson JS, Ribeiro Gonçalves RC, Oliveira TB, Barreto da Silva V, Kawano DF, Kitagawa RR Tags: Curr Top Med Chem Source Type: research
Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI
Abstract
Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research
Biomarker Analyses of Clinical Outcomes in Patients With Advanced Hepatocellular Carcinoma Treated With Sorafenib With or Without Erlotinib in the SEARCH Trial.
CONCLUSIONS: Baseline plasma HGF, VEGF-A, KIT, and VEGF-C correlated with clinical outcomes in HCC patients treated with sorafenib with or without erlotinib. These biomarkers plus epigen constituted a multimarker signature for improved OS.
PMID: 27220960 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 23, 2016 Category: Cancer & Oncology Authors: Zhu AX, Kang YK, Rosmorduc O, Evans TR, Santoro A, Ross P, Gane E, Vogel A, Jeffers M, Meinhardt G, Pena C Tags: Clin Cancer Res Source Type: research
Characterizing Diagnostic Search Patterns in Digital Breast Pathology: Scanners and Drillers
AbstractFollowing a baseline demographic survey, 87 pathologists interpreted 240 digital whole slide images of breast biopsy specimens representing a range of diagnostic categories from benign to atypia, ductal carcinoma in situ, and invasive cancer. A web-based viewer recorded pathologists ’ behaviors while interpreting a subset of 60 randomly selected and randomly ordered slides. To characterize diagnostic search patterns, we used the viewport location, time stamp, and zoom level data to calculate four variables: average zoom level, maximum zoom level, zoom level variance, and scan ning percentage. Two distinct search ...
Source: Journal of Digital Imaging - July 5, 2017 Category: Radiology Source Type: research
