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Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism
In this study, we analyzed the enantiomers of mitotane and o,p'-DDA in the plasma of patients by a newly developed chiral-phase method employed in two-dimensional chromatography. Important differences were observed in the ratio of (S)/(R)-mitotane, which varied substantially from 1:1.2 to 1:10 whereas the (S)/(R)-o,p'-DDA ratio was relatively conserved, at approximately 2:1. These findings provide evidence for the enantioselective metabolism and provide a method for further analyses of mitotane and metabolites, which can explain the variation in the therapeutic response.PMID:37713949 | DOI:10.1016/j.bioorg.2023.106835
Source: Bioorganic Chemistry - September 15, 2023 Category: Chemistry Authors: Gabriela Stadler Alan de Almeida Veiga Claudia Rita Corso Camila Bach de Assis Beatriz de Toledo Nogueira Lucia Regina Rocha Martins Beatriz Cruz Bonk Fl ávia Lada Degaut Pontes Bonald Cavalcante de Figueiredo Lauro Mera de Souza Source Type: research

Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases
Fitoterapia. 2023 Jul 25:105624. doi: 10.1016/j.fitote.2023.105624. Online ahead of print.ABSTRACTCordia oncocalyx Allemão is an endemic economically underexploited plant from Brazilian semi-arid region. Herein, we carried out a well-defined bibliographic review about the pharmacological activities of oncocalyxones from C. oncocalyx and mechanisms responsible for the biomedical properties. MeSH terms were used in the scientific databases for a narrative exploration. Technological development and bioproducts were also examined. Cordia oncocalyx is a deciduous tree of sexual reproduction rich in terpenoid quinones. Among th...
Source: Fitoterapia - July 27, 2023 Category: Biochemistry Authors: Paulo Michel Pinheiro Ferreira Antonia Amanda Cardoso de Almeida Micaely Lorrana Pereira Concei ção Ot ília Deusdênia Loiola Pessoa Lana Grasiela Alves Marques Raffaele Capasso Cl áudia Pessoa Source Type: research

Cytotoxic mixed-ligand copper(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives
New J. Chem., 2023, Advance Article DOI: 10.1039/D3NJ00568B, PaperEkaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Alexey S. Berezin, Leonid N. Fetisov, Alexandra E. Svyatogorova, Natalia O. Andros, Alexander A. Zubenko, Elizaveta V. Lider 1,10-Phenanthroline and 2,2 ′-bipyridine based copper(II) complexes with 1H-tetrazole-5-acetic acid as anticancer agents selective against hepatocellular carcinoma cells have been synthesized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - May 2, 2023 Category: Chemistry Authors: Ekaterina A. Ermakova Source Type: research

Clinical analysis of immune function and intestinal flora changes in patients with oral squamous carcinoma before and after treatment
CONCLUSIONS: Conventional treatment remarkably enhances immune function, revitalizes the distribution of intestinal microflora, elevates the content of short-chain fatty acids in the intestine of OSCC patients, thereby improving the patients' health.PMID:36758602
Source: Shanghai Journal of Stomatology - February 9, 2023 Category: Dentistry Authors: Yi Qian Chao Deng Xiao-Bo Xu Ye-Jun Chen Yun-Ping Hu Li-Lin Hong Da-Jun Feng Source Type: research

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