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A new era of macrophage-based cell therapy
Experimental & Molecular Medicine, Published online: 01 September 2023; doi:10.1038/s12276-023-01068-zTreating disease with the white blood cells called macrophages, in some cases genetically modified, could become an effective clinical option for a range of diseases. Macrophages are cells of the innate (non-specific) immune system that can destroy diseased cells or damaging materials. They can also enhance tissue repair by releasing growth factors and anti-inflammatory molecules. Seung Hyeok Seok and colleagues at Seoul National University in South Korea review the laboratory research and clinical trials that are inve...
Source: Experimental and Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Yi Rang Na Sang Wha Kim Seung Hyeok Seok Source Type: research

Galangin as an inflammatory response modulator: An updated overview and therapeutic potential
Chem Biol Interact. 2023 Apr 10:110482. doi: 10.1016/j.cbi.2023.110482. Online ahead of print.ABSTRACTNumerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2),...
Source: Chemico-Biological Interactions - April 12, 2023 Category: Molecular Biology Authors: Riya Thapa Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Ahsas Goyal Waleed Hassan Almalki Sami I Alzarea Imran Kazmi Vikash Jakhmola Sachin Kumar Singh Kamal Dua Ritu Gilhotra Gaurav Gupta Source Type: research

Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy
Mol Biol (Mosk). 2023 Mar-Apr;57(2):360-361.ABSTRACTType 2 Diabetes Mellitus (T2DM) and cardiac hypertrophy (CH) are among the top ten leading cause of deaths, worldwide. T2DM and cardiac hypertrophy are the chronic diseases, have close association and direct life-threatening complications like stroke, myocardial infarction, retinopathy, nephropathy, and limb amputation. In addition to other medical approaches, miRNAs-based strategy is considered most efficient for early detection of chronic diseases and also has potential for the treatment of T2DM and cardiac hypertrophy like it is being used for cancer in clinical trials...
Source: Molekuliarnaia Biologiia - March 31, 2023 Category: Molecular Biology Authors: K Hussain A Ishtiaq I Mushtaq I Murtaza Source Type: research

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