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The Role of Epsilon PKC in Acute and Chronic Diseases: Possible Pharmacological Implications of its Modulators
Publication date: Available online 25 July 2016 Source:Pharmacological Research Author(s): Barbara Capuani, Francesca Pacifici, Donatella Pastore, Raffaele Palmirotta, Giulia Donadel, Roberto Arriga, Alfonso Bellia, Nicola di Daniele, Paola Rogliani, Pasquale Abete, Paolo Sbraccia, Fiorella Guadagni, Davide Lauro, David Della-Morte Epsilon Protein kinase C (εPCK) is a particular kinase that, when activated, is able to protect against different stress injuries and therefore has been proposed to be a potential molecular target against acute and chronic diseases. Particular attention has been focused on εPCK...
Source: Pharmacological Research - July 25, 2016 Category: Drugs & Pharmacology Source Type: research

Dioscin: a diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections
Publication date: Available online 10 October 2018Source: Pharmacological ResearchAuthor(s): Xufeng Tao, Lianhong Yin, Lina Xu, Jinyong PengAbstractCurrently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It’s critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. In recent years, dioscin has reached more and more attention with its potent effects to treat ...
Source: Pharmacological Research - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization
In conclusion, we have established a novel role for FPR-1 in VSMC contractility and motility, similar to the one observed in sentinel cells of the innate immune system. This discovery is fundamental for vascular immuno-pathophysiology, given that FPR-1 in VSMCs not only functions as an immune system receptor, but it also has an important role for the dynamic plasticity of arteries.Graphical AbstractSchematic proposing that formyl peptide receptor-1 (FPR-1) play a role in the vascular function. Formyl peptide receptor (FPR-1), an innate immune system receptor, mediates vascular plasticity during physiological conditions. Up...
Source: Pharmacological Research - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

The therapeutic role of long non-coding RNAs in human diseases; a focus on the recent insights into autophagy
Publication date: Available online 8 February 2019Source: Pharmacological ResearchAuthor(s): Samira Barangi, A. Wallace Hayes, Russel Reiter, Gholamreza KarimiAbstractLong non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. The impairment of the autophagy process ha...
Source: Pharmacological Research - February 9, 2019 Category: Drugs & Pharmacology Source Type: research

The therapeutic role of long non-coding RNAs in human diseases: A focus on the recent insights into autophagy
Publication date: April 2019Source: Pharmacological Research, Volume 142Author(s): Samira Barangi, A. Wallace Hayes, Russel Reiter, Gholamreza KarimiAbstractLong non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. The impairment of the autophagy process has been des...
Source: Pharmacological Research - February 14, 2019 Category: Drugs & Pharmacology Source Type: research