Dioscin: a diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections

Publication date: Available online 10 October 2018Source: Pharmacological ResearchAuthor(s): Xufeng Tao, Lianhong Yin, Lina Xu, Jinyong PengAbstractCurrently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It’s critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. In recent years, dioscin has reached more and more attention with its potent effects to treat liver, kidney, brain, stomach and intestine damages, and metabolic diseases including diabetes, osteoporosis, obesity, hyperuricemia as well as its anti-cancer activities through adjusting multiple targets and multiple signals. Therefore, dioscin is a promising multi-target candidate to treat various diseases. This review paper summarized the progress on pharmacological activities and mechanisms of dioscin, which may provide useful data for development and exploration of this natural product in the further.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Surendra Gulla, Dakshayani Lomada, Vadali V.S.S. Srikanth, Muthukonda Venkatakrishnan Shankar, Kakarla Raghava Reddy, Sarvesh Soni, Madhava C. ReddyAbstractNanoparticles' based cancer therapeutics are greatly dependent on the development of science and engineering of nanoparticles. In this article, important strategies based on nanoparticles used for cancer treatment are discussed. The inspiration to write this article is not only to review the existing strategies based on nanoparticles but also to highlight the pertinent and possible solutions ther...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic metho...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 22 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Mohammed Shariq Iqbal, Asif Jafri, Md Arshad, Mohammad Israil AnsariAbstractNigella sativa is a potent medicinal plant having remarkable antioxidant property. More than hundred phytochemicals known for this plant, thymoquinone is one of the major active and strong antioxidative phyto-constituent found in it. Thymoquinone being a cyclicdione, reacts with sodium azide to synthesize its analogs α-azido ketones that are versatile with wide variety of reactions. The stress produced due to sodium azide, modulates the...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
PMID: 31109499 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109488 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109486 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract OBJECTIVE: To review visual and anatomic outcomes after cataract surgery with complications in a teaching institution. METHODS: Consecutive case series. A chart review was conducted of patients who underwent phacoemulsification with intraoperative or postoperative complications, performed by ophthalmology residents under direct supervision of experienced ophthalmology attending physicians. Best corrected visual acuity (BCVA), OCT parameters, and postoperative treatments were reviewed at 1, 3, 6, and 12 months postoperatively. RESULTS: One hundred thirty-three eyes were analyzed. Mean BCVA was 50...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract OBJECTIVE: To determine the use of home care services in those with and without visual impairment in Canada. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Participants came from the baseline examination of the Canadian Longitudinal Study on Aging Comprehensive Cohort. Inclusion criteria included age between 45 and 85 years, community dwelling, and living near one of the 11 data collection sites across 7 Canadian provinces. People were excluded if they were in an institution, were living on a First Nations reserve, were full-time members of the Canadian Armed Forces, did not speak...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSION: The FFCEs generated at the hospital service corridor by an urban community DR screening teleophthalmology project did not impact negatively on its services; moreover, the service corridor was exempted from providing FFCEs to 87.4% of the diabetic population it serves. This study may help provide cost-efficiency indications for a screening protocol that would include OCT availability at the imaging site and measure its positive effects. While DR of which DME was the main cause of referral for FFCE, incidental significant sight-threatening findings were significant and approached DR as a cause of referral; this s...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
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