• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

RPL39, MLF2 alter tumor initiation and metastasis Cell Biology
We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal. Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and...
Source: Proceedings of the National Academy of Sciences - June 17, 2014 Category: Science Authors: Dave, B., Granados-Principal, S., Zhu, R., Benz, S., Rabizadeh, S., Soon-Shiong, P., Yu, K.-D., Shao, Z., Li, X., Gilcrease, M., Lai, Z., Chen, Y., Huang, T. H.- M., Shen, H., Liu, X., Ferrari, M., Zhan, M., Wong, S. T. C., Kumaraswami, M., Mittal, V., Ch Tags: Biological Sciences Source Type: research

Radiation killing is regulated by LGP2 Medical Sciences
An siRNA screen targeting 89 IFN stimulated genes in 14 different cancer cell lines pointed to the RIG-I (retinoic acid inducible gene I)–like receptor Laboratory of Genetics and Physiology 2 (LGP2) as playing a key role in conferring tumor cell survival following cytotoxic stress induced by ionizing radiation (IR). Studies...
Source: Proceedings of the National Academy of Sciences - January 28, 2014 Category: Science Authors: Widau, R. C., Parekh, A. D., Ranck, M. C., Golden, D. W., Kumar, K. A., Sood, R. F., Pitroda, S. P., Liao, Z., Huang, X., Darga, T. E., Xu, D., Huang, L., Andrade, J., Roizman, B., Weichselbaum, R. R., Khodarev, N. N. Tags: PNAS Plus Source Type: research

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells.
Conclusions: The expression of eIF5A-2 was up-regulated following EMT phenotype changes in A549 cells, which correlated with enhanced tumor invasion and metastatic capabilities. Furthermore, in the A549 cell line, the process of EMT phenotype change could be reversed by eIF5A-2 siRNA, with a consequent weakening of both invasive and metastatic capabilities. PMID: 23733422 [PubMed - in process]
Source: J Zhejiang Univ Sci ... - June 1, 2013 Category: Science Authors: Xu GD, Shi XB, Sun LB, Zhou QY, Zheng DW, Shi HS, Che YL, Wang ZS, Shao GF Tags: J Zhejiang Univ Sci B Source Type: research

Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells.
This study was focused on investigating the effect of small interfering RNA (siRNA)-mediated eIF3c gene knockdown on colon cancer cell survival. The eIF3c gene was observed to be highly expressed in colon cancer cell models. The expression levels of the gene in eIF3c siRNA infected and control siRNA infected cells were compared via real-time polymerase chain reaction (PCR) and western blotting analysis. Cell proliferation levels were analyzed employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Furthermore, the effects of eIF3c gene knockdown on the cell cycle and apopto...
Source: J Zhejiang Univ Sci ... - June 1, 2013 Category: Science Authors: Song N, Wang Y, Gu XD, Chen ZY, Shi LB Tags: J Zhejiang Univ Sci B Source Type: research

Pages: 1  2