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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
Antiviral Res. 2022 Jun 20;204:105367. doi: 10.1016/j.antiviral.2022.105367. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to global health. We previously reported that AAK1, BIKE and GAK, members of the Numb-associated kinase family, control intracellular trafficking of multiple RNA viruses during viral entry and assembly/egress. Here, using both genetic and pharmacological approaches, we probe the functional relevance of NAKs for SARS-CoV-2 infection. siRNA-mediated depletion of AA...
Source: Antiviral Research - June 23, 2022 Category: Virology Authors: Marwah Karim Sirle Saul Luca Ghita Malaya Kumar Sahoo Chengjin Ye Nishank Bhalla Chieh Wen Lo Jing Jin Jun-Gyu Park Bel én Martinez-Gualda Michael Patrick East Gary L Johnson Benjamin A Pinsky Luis Martinez-Sobrido Christopher R M Asquith Aarthi Narayana Source Type: research

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