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Total 27 results found since Jan 2013.
Effects of Smoking on Long-Term Clinical Outcomes and Lung Cancer in Patients with Acute Myocardial Infarction
CONCLUSIONS: In contrast to the unadjusted model, smoking is associated with worse cardiovascular outcome and higher incidence of lung cancer after adjustment of various confounding factors. This result can be explained by the characteristics of smokers, which were young and had fewer comorbidities.PMID:33821583 | PMC:PMC8022024 | DOI:10.4070/kcj.2020.0430
Source: Korean Circulation Journal - April 6, 2021 Category: Cardiology Authors: Su Nam Lee Ik Jun Choi Sungmin Lim Eun Ho Choo Byung Hee Hwang Chan Joon Kim Mahn Won Park Jong Min Lee Chul Soo Park Hee Yeol Kim Ki Dong Yoo Doo Soo Jeon Ho Joong Youn Wook Sung Chung Min Chul Kim Myung Ho Jeong Youngkeun Ahn Kiyuk Chang Source Type: research
Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
