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Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced cell death of stomach adenocarcinoma cells in vitro.
Abstract Oncolytic viruses can kill malignant cells while sparing normal cells. Multiple pathways are involved in this action. The antitumor effects of viral infection on SGC-7901 and AGS cells were investigated. We measured endoplasmic reticulum stress and autophagy caused by the recombinant avirulent Newcastle disease virus (NDV) LaSota strain expressing the rabies virus glycoprotein (rL-RVG) and the NDV wild-type strain. The dose-response curves were analyzed using the MTT assay. The expression of RVG was detected by western blotting, RT-PCR and immunofluorescence analyses. Cell death and autophagy were observe...
Source: International Journal of Oncology - June 9, 2015 Category: Cancer & Oncology Authors: Bu XF, Wang MB, Zhang ZJ, Zhao YH, Li M, Yan YL Tags: Int J Oncol Source Type: research

LaSota Strain Expressing The Rabies Virus Glycoprotein (rL-RVG) Suppresses Gastric Cancer by Inhibiting the Alpha 7 Nicotinic Acetylcholine Receptor ( α7 nAChR)/Phosphoinositide 3-Kinase (PI3K)/AKT Pathway.
CONCLUSIONS rL-RVG leads to much greater apoptosis through the alpha7-nAChR/PI3K/AKT pathway. PMID: 31337746 [PubMed - in process]
Source: Medical Science Monitor - July 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research