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Haemophagocytic lymphohistiocytosis following a COVID-19 infection: case report
The case of a 57-year-old male patient with jaundice, high-grade fever, and upper abdominal pain who was recovering from a mild coronavirus disease-19 (COVID-19) infection is reported. Laboratory analysis showed liver injury with high levels of AST and ALT, as well as an elevated serum ferritin level. The patient underwent a bone marrow biopsy which showed features of hemophagocytic lymphohistiocytosis (HLH), a systemic syndrome caused by immune activation. The patient was successfully treated with etoposide and dexamethasone and kept on maintenance therapy with cyclosporine, with resolution of the HLH.The discussion highl...
Source: The Journal of Infection in Developing Countries - March 30, 2023 Category: Infectious Diseases Authors: Jonathan Soldera, Guilherme Rasia Bosi Source Type: research

A Case of Left Ventricular Thrombus and Herpetic Esophagitis in an Immunocompetent Patient With COVID-19
This report describes a case of a 57-year-old male patient who presented to the hospital with altered mental status and a positive SARS-CoV-2 polymerase chain reaction (PCR) test. CT of the chest revealed the presence of an LVT, and transthoracic echocardiography showed a reduced ejection fraction and confirmed the presence of the thrombus. The patient also reported epigastric chest pain and several bloody bowel movements. A colonoscopy revealed internal hemorrhoids. An esophagogastroduodenoscopy revealed the presence of multiple esophageal ulcers, and biopsy results confirmed herpes simplex virus (HSV) infection. The pati...
Source: Herpes - February 15, 2023 Category: Infectious Diseases Authors: Ayman Mohamed Harish Gidda Shirin Zavoshi Rabia Mahmood Source Type: research

A case of Hemophagocytic lymphohistiocytosis induced by COVID-19, and review of all cases reported in the literature
Novel coronavirus infections 2019 (COVID-19) associated hyperinflammatory syndromes are well-defined clinical conditions and have a potential risk for severe infection. Hemophagocytic lymphohistiocytosis (HLH), a rare type of acute progressive hyperinflammatory syndrome, has been reported in a limited number of COVID-19 cases. In this article, we aimed to present a patient with HLH secondary to COVID-19 diagnosed by bone marrow biopsy, and to summarize and review HLH cases associated with COVID-19 in the literature.A 47-year-old male patient presented with complaints of fever, cough, abdominal discomfort, and nausea-vomiti...
Source: The Journal of Infection in Developing Countries - November 30, 2021 Category: Infectious Diseases Source Type: research