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SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis
The objective of this study is to test the effect of SARS-CoV-2-f ree proteins on the metabolic and immune responses of macrophages. We hypothesized that SARS-CoV-2 proteins shed during the infection cycle may dynamically induce metabolic and immunologic alterations with an inflammatory impact on the infected host cells. It is imperative to delineate such alterati ons in the context of macrophages to gain insight into the pathogenesis of these highly infectious viruses and their associated complications and thus, expedite the vaccine and drug therapy advent in combat of viral infections. Human monocyte-derived macrophages ...
Source: PLoS One - January 19, 2023 Category: Biomedical Science Authors: Mohammad G. Mohammad Source Type: research

Potential Genes Associated with COVID-19 and Comorbidity
In this study, we identified 11 genes associated with both COVID-19 and three comorbidities that may contribute to infection and disease severity. The key genes IL6 and AGT are involved in regulating immune response, cytokine activity, and viral infection. Therefore, RAAS inhibitors, AGT antisense nucleotides, cytokine inhibitors, vitamin D, fenofibrate, and vaccines regulating non-immune and immune factors could be potential strategies to prevent and cure COVID-19. The study provides a basis for further investigation of genes and pathways with predictive value for the risk of infection and prognosis and could help guide d...
Source: International Journal of Medical Sciences - February 15, 2022 Category: Biomedical Science Authors: Shanshan Feng Fuqiang Song Wenqiong Guo Jishan Tan Xianqin Zhang Fengling Qiao Jinlin Guo Lin Zhang Xu Jia Source Type: research

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