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Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children
Fecal microbiota transplantation (FMT) is currently the most effective but loosely regulated therapy, for recurrent Clostridioides difficile infection (rCDI) in pediatrics. Over the last 2 years, there have been mounting challenges in the ability to provide FMT to pediatric patients. Firstly, an Food and Drug Administration (FDA) safety alert in 2019 reported transmission of a multidrug resistant organism from FMT donor to recipient resulting in the death of 1 patient. Secondly, the coronavirus disease 2019 (COVID-19) pandemic induced further safety and regulatory challenges. Biotherapeutics are promising and more readily ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 29, 2021 Category: Gastroenterology Tags: Topic of the Month Source Type: research

Diagnostic syndromic multiplex approaches for gastrointestinal infections
Expert Rev Gastroenterol Hepatol. 2021 Mar 8. doi: 10.1080/17474124.2021.1899807. Online ahead of print.ABSTRACTIntroduction: Gastrointestinal diseases due to infectious pathogens currently represent an important global health concern, especially in children and developing countries. Early and accurate detection of gastrointestinal pathogens is important to initiate the appropriate type of therapy. Multiplex molecular gastrointestinal panels rapidly detect several gastrointestinal pathogens at once with high sensitivity.Areas covered: We assess the scope and limitations of several multiplex gastrointestinal panels approved...
Source: Expert Review of Gastroenterology and Hepatology - March 8, 2021 Category: Gastroenterology Authors: H éctor Jesús Maldonado-Garza Elvira Garza-Gonz ález Paola Bocanegra-Ibarias Samantha Flores-Trevi ño Source Type: research