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Intravenous immunoglobulin and rituximab in a treatment ‐refractory COVID‐19‐associated central nervous system vasculitis: A case report and literature review
In this study, we present the first case of treatment-refractory CNS vasculitis associated with COVID-19, which was treated successfully with intravenous immunoglobulin and rituximab. Second, we repo rt a review of COVID-19-related CNS vasculitis articles and applied treatment strategies published in English. To elucidate the mechanism of COVID-19-related CNS vasculitis, further research is needed.
Source: Clinical and Experimental Neuroimmunology - July 19, 2023 Category: Neurology Authors: Onur Anil Mutlu, Merve İriş, Nursena Erener, Osman Kizilkiliç, Civan Işlak, Emire Seyahi, Sabahattin Saip, Uğur Uygunoğlu Tags: REVIEW ARTICLE Source Type: research

Recurrent Acute Disseminated Encephalomyelitis (ADEM) after COVID-19-vaccination and after subsequent COVID-19-infection: A case report (part II)
Acute disseminated encephalomyelitis (ADEM) is an autoimmune disorder of the central nervous system (CNS), which is commonly associated to previous viral infection or immunization. Cases of ADEM with a potential relationship to both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination have been reported. We recently published a rare case of a 65-year-old patient who suffered from a corticosteroid- and immunoglobulin-refractory multiple autoimmune syndrome including ADEM following Pfizer-BioNTech coronavirus disease (COVID)-19 vaccination, and whose symptoms largely resolved after repeated ...
Source: Frontiers in Neurology - March 10, 2023 Category: Neurology Source Type: research

Case report: A case of acute disseminated encephalomyelitis after SARS-CoV-2 infection in pediatric patients
ConclusionThis clinical case confirms that SARS-CoV-2 infections are increasingly implicated in severe neurological consequences in both adult and pediatric patients. While the most frequent complications that were reported in children included headache, altered mental status, and encephalopathy, ~5% of the individuals suffered from severe neurological complications, leading to lifelong sequelae. All physicians must be aware of these data and detect neurological signs of severe (or not) complications that require a specific follow-up and treatment.
Source: Frontiers in Neurology - February 22, 2023 Category: Neurology Source Type: research