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Tenofovir disoproxil fumarate/emtricitabine and severity of coronavirus disease 2019 in people with HIV infection
Discussion: Compared with other antiretrovirals, TDF/FTC lowers COVID-19 severity among HIV-positive individuals with virological control. This protective effect may be restricted to individuals aged 50 years and older.
Source: AIDS - November 17, 2022 Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research

Tenofovir disoproxil fumarate and coronavirus disease 2019 outcomes in men with HIV
Objective: To compare the risk of coronavirus disease 2019 (COVID-19) outcomes by antiretroviral therapy (ART) regimens among men with HIV. Design: We included men with HIV on ART in the Veterans Aging Cohort Study who, between February 2020 and October 2021, were 18 years or older and had adequate virological control, CD4+ cell count, and HIV viral load measured in the previous 12 months, and no previous COVID-19 diagnosis or vaccination. Methods: We compared the adjusted risks of documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, COVID-19-related hospitalization, and ...
Source: AIDS - September 10, 2022 Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research

Computational screening of dual inhibitors from FDA approved antiviral drugs on SARS-CoV-2 spike protein and the main protease using molecular docking approach
Acta Virol. 2021;65(2):160-172. doi: 10.4149/av_2021_208.ABSTRACTThe deadly disease-causing novel coronavirus has recently swept across the world and endangered many human lives. Although, various research on therapeutic measures to solve this pandemic crisis has been published; no favourable results have been achieved. We propose the use of potential FDA-approved dual inhibitors which can inhibit two targets (either on entry-level or the main protease) for the effective treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We screened 12 FDA-approved antiviral inhibitors listed in Drug bank and analys...
Source: Acta Virologica - June 16, 2021 Category: Infectious Diseases Authors: Shanthi Sabarimurugan Indu Purushothaman Rajarajan Swaminathan Arun Dharmarajan Sudha Warrier Sangeetha Kothandan Source Type: research

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