International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours – EURO EWING 2012 Protocol
This study will establish which is the “standard regimen” of chemotherapy, taking into account both clinical outcomes and toxicity. This will form the chemotherapy backbone for future interventional studies where we may want to add new targeted agents. It will also determine the role of zoledronic acid in conjunction with the separat e EE2008 trial. Any trial in ESFT needs to take into account the rarity of the tumour and consider that international cooperation is needed to provide answers in a timely manner.Trial registrationRegistered with EudraCT number 2012-002107-17 on 26 February 2012. Registered with ISRCTN numb...
Source: Trials - January 16, 2020 Category: Research Source Type: clinical trials
Treating Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density With Denosumab or Zoledronic Acid
Conditions: Idiopathic Inflammatory Myopathies; Osteoporosis, Osteopenia Interventions: Drug: Denosumab; Drug: Zoledronic Acid Sponsors: Kwong Wah Hospital; Tung Wah Group of Hospitals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 26, 2019 Category: Research Source Type: clinical trials
Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.
Condition: Carcinoma, Non-Small-Cell Lung Interventions: Biological: Tyrosine Kinase Inhibitor; Drug: Zoledronic Acid 4 MG/100 ML Intravenous Solution [ZOMETA]; Drug: Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA] Sponsors: University of Colorado, Denver; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 22, 2019 Category: Research Source Type: clinical trials
