In Mouse Model, Small Peptide Ameliorates Autoimmune Skin Blistering Disease
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 10, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
In Vitro Pathogenicity Assay for Anti-desmoglein Autoantibodies in Pemphigus
We describe here two assays that measure the pathogenic strength of autoantibodies in blister formation: an in vitro dissociation assay using primary human epidermal keratinocytes to assess pathogenicity of anti-Dsg3 autoantibodies, and an alternative method whereby anti-Dsg3 and Dsg1 autoantibodies are injected into organ-cultured human skin specimen. (Source: Springer protocols feed by Molecular Medicine)
Source: Springer protocols feed by Molecular Medicine - December 19, 2012 Category: Molecular Biology Source Type: news
