A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial
AbstractObjectivesThe primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin ®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of interleukin-6 (IL-6). Secondary objectives are to determine the effects of intravenous Prolastin® on important clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs).Trial designPhase 2, randomised, double-blind, placebo-controlled, pilot trial.ParticipantsThe study will be co...
Source: Trials - April 19, 2021 Category: Research Source Type: clinical trials

Phase 2 Studying the Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia (CLL) With History of Non-melanoma Skin Cancers (NMSC)
Condition:   Chronic Lymphocytic Leukemia Interventions:   Drug: Nicotinamide;   Drug: Placebo Sponsor:   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 14, 2021 Category: Research Source Type: clinical trials

Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia (CLL) With History of Non-melanoma Skin Cancers (NMSC)
Condition:   Chronic Lymphocytic Leukemia Interventions:   Drug: Nicotinamide;   Drug: Placebo Sponsor:   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 14, 2021 Category: Research Source Type: clinical trials

Phase 2 Studying the Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia (CLL) With History of Non-melanoma Skin Cancers (NMSC)
Condition:   Chronic Lymphocytic Leukemia Interventions:   Drug: Nicotinamide;   Drug: Placebo Sponsor:   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 14, 2021 Category: Research Source Type: clinical trials

Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia (CLL) With History of Non-melanoma Skin Cancers (NMSC)
Condition:   Chronic Lymphocytic Leukemia Interventions:   Drug: Nicotinamide;   Drug: Placebo Sponsor:   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 14, 2021 Category: Research Source Type: clinical trials