Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Introducing Developmental Signaling into Adults in Order to Produce Regeneration
Is it possible to safely introduce developmental signaling characteristic of the developing embryo and fetus into an aged adult in order to spur greater regeneration of tissues? The past decades of work on embryonic stem cell therapies and induced pluripotent stem cell therapies, and the slow investigation of how most of these therapies produce their benefits via cell signaling, suggest that this goal is in principle possible. Similarly, research into species capable of proficient regeneration, such as salamanders and zebrafish, suggests broad similarities between the biochemistry of organ development and the biochemistry ...
Source: Fight Aging! - June 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What men need to know about breast cancer
We all know what the American Cancer Society, the American College of Radiology, and countless other professional societies recommend regarding screening and diagnosing breast cancer in women. But a subject that comes up far less frequently is what to do with men. While it is significantly lower than in women, a man’s risk is not nearly as low as we might think: one in a thousand will get breast cancer in his lifetime.
As with women, everything that increases estrogen in a man puts the breast tissue he was born with at an increased risk of developing malignancy. Chemicals and pollutants, obesity, radiation — all th...
Source: Kevin, M.D. - Medical Weblog - July 18, 2015 Category: Journals (General) Authors: Nicole Saphier, MD Tags: Conditions Cancer Source Type: blogs
