Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry < em > in vitro < /em >
Vet Q. 2023 Jul 21:1-15. doi: 10.1080/01652176.2023.2240380. Online ahead of print.ABSTRACTImmune escape is the hallmark of carcinogenesis. This widely-known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy. Therefore, cancer immunotherapy with specific binding to these receptors has been developed to treat human cancers. Due to the lack of cross-reactivity of these antibodies in dogs, a specific canine PD-1/PD-L1 antibody is required. The aim of this study is to develop mouse anti-canine PD-L1 (cPD-L1)...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Sirintra Sirivisoot Chatikorn Boonkrai Tossapon Wongtangprasert Tanapati Phakham Phijitra Muanwein Trairak Pisitkun Chenphop Sawangmake Araya Radtanakatikanon Anudep Rungsipipat Source Type: research
Ultrasonographic Features of Gallbladder Wall Thickening in Dogs with Hypoalbuminemia
Vet Q. 2023 Jul 21:1-8. doi: 10.1080/01652176.2023.2240381. Online ahead of print.ABSTRACTHypoalbuminemia has been considered as a cause of gallbladder wall thickening in humans and dogs. Recent study revealed that gallbladder wall thickening in dogs with hypoalbuminemia may not be associated with serum albumin/plasma levels within 48-hour of ultrasound study. However, gallbladder wall edema may change within 48-hour, and the ultrasonographic features of gallbladder wall thickening in dogs with hypoalbuminemia have not been reported. The purpose of this study is to describe the relationship between serum albumin levels wit...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Masahiro Murakami Hock Gan Heng Sarah Steinbach Mario Sola Source Type: research
Genome analysis of clinical genotype < em > Vibrio vulnificus < /em > isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity
Vet Q. 2023 Jul 21:1-36. doi: 10.1080/01652176.2023.2240389. Online ahead of print.ABSTRACTVibrio vulnificus an opportunistic human pathogen native to marine/estuarine environments, is one of the leading causes of death due to seafood consumption and exposure of wounds to seawater worldwide. The present study involves the whole genome sequence analysis of an environmental strain of V. vulnificus (clinical genotype) isolated from seafood along the Mangaluru coast of India. The sequenced genome data was subjected to in-silico analysis of phylogeny, virulence genes, antimicrobial resistance determinants and secretary proteins...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Kattapuni Suresh Prithvisagar Pavan Gollapalli Caroline D'Souza Praveen Rai Iddya Karunasagar Indrani Karunasagar Ballamoole Krishna Kumar Source Type: research
Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry < em > in vitro < /em >
Vet Q. 2023 Jul 21:1-15. doi: 10.1080/01652176.2023.2240380. Online ahead of print.ABSTRACTImmune escape is the hallmark of carcinogenesis. This widely-known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy. Therefore, cancer immunotherapy with specific binding to these receptors has been developed to treat human cancers. Due to the lack of cross-reactivity of these antibodies in dogs, a specific canine PD-1/PD-L1 antibody is required. The aim of this study is to develop mouse anti-canine PD-L1 (cPD-L1)...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Sirintra Sirivisoot Chatikorn Boonkrai Tossapon Wongtangprasert Tanapati Phakham Phijitra Muanwein Trairak Pisitkun Chenphop Sawangmake Araya Radtanakatikanon Anudep Rungsipipat Source Type: research
Ultrasonographic Features of Gallbladder Wall Thickening in Dogs with Hypoalbuminemia
Vet Q. 2023 Jul 21:1-8. doi: 10.1080/01652176.2023.2240381. Online ahead of print.ABSTRACTHypoalbuminemia has been considered as a cause of gallbladder wall thickening in humans and dogs. Recent study revealed that gallbladder wall thickening in dogs with hypoalbuminemia may not be associated with serum albumin/plasma levels within 48-hour of ultrasound study. However, gallbladder wall edema may change within 48-hour, and the ultrasonographic features of gallbladder wall thickening in dogs with hypoalbuminemia have not been reported. The purpose of this study is to describe the relationship between serum albumin levels wit...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Masahiro Murakami Hock Gan Heng Sarah Steinbach Mario Sola Source Type: research
Genome analysis of clinical genotype < em > Vibrio vulnificus < /em > isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity
Vet Q. 2023 Jul 21:1-36. doi: 10.1080/01652176.2023.2240389. Online ahead of print.ABSTRACTVibrio vulnificus an opportunistic human pathogen native to marine/estuarine environments, is one of the leading causes of death due to seafood consumption and exposure of wounds to seawater worldwide. The present study involves the whole genome sequence analysis of an environmental strain of V. vulnificus (clinical genotype) isolated from seafood along the Mangaluru coast of India. The sequenced genome data was subjected to in-silico analysis of phylogeny, virulence genes, antimicrobial resistance determinants and secretary proteins...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Kattapuni Suresh Prithvisagar Pavan Gollapalli Caroline D'Souza Praveen Rai Iddya Karunasagar Indrani Karunasagar Ballamoole Krishna Kumar Source Type: research
Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry < em > in vitro < /em >
Vet Q. 2023 Jul 21:1-15. doi: 10.1080/01652176.2023.2240380. Online ahead of print.ABSTRACTImmune escape is the hallmark of carcinogenesis. This widely-known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy. Therefore, cancer immunotherapy with specific binding to these receptors has been developed to treat human cancers. Due to the lack of cross-reactivity of these antibodies in dogs, a specific canine PD-1/PD-L1 antibody is required. The aim of this study is to develop mouse anti-canine PD-L1 (cPD-L1)...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Sirintra Sirivisoot Chatikorn Boonkrai Tossapon Wongtangprasert Tanapati Phakham Phijitra Muanwein Trairak Pisitkun Chenphop Sawangmake Araya Radtanakatikanon Anudep Rungsipipat Source Type: research
Ultrasonographic Features of Gallbladder Wall Thickening in Dogs with Hypoalbuminemia
Vet Q. 2023 Jul 21:1-8. doi: 10.1080/01652176.2023.2240381. Online ahead of print.ABSTRACTHypoalbuminemia has been considered as a cause of gallbladder wall thickening in humans and dogs. Recent study revealed that gallbladder wall thickening in dogs with hypoalbuminemia may not be associated with serum albumin/plasma levels within 48-hour of ultrasound study. However, gallbladder wall edema may change within 48-hour, and the ultrasonographic features of gallbladder wall thickening in dogs with hypoalbuminemia have not been reported. The purpose of this study is to describe the relationship between serum albumin levels wit...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Masahiro Murakami Hock Gan Heng Sarah Steinbach Mario Sola Source Type: research
Genome analysis of clinical genotype < em > Vibrio vulnificus < /em > isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity
Vet Q. 2023 Jul 21:1-36. doi: 10.1080/01652176.2023.2240389. Online ahead of print.ABSTRACTVibrio vulnificus an opportunistic human pathogen native to marine/estuarine environments, is one of the leading causes of death due to seafood consumption and exposure of wounds to seawater worldwide. The present study involves the whole genome sequence analysis of an environmental strain of V. vulnificus (clinical genotype) isolated from seafood along the Mangaluru coast of India. The sequenced genome data was subjected to in-silico analysis of phylogeny, virulence genes, antimicrobial resistance determinants and secretary proteins...
Source: Veterinary Quarterly - July 21, 2023 Category: Veterinary Research Authors: Kattapuni Suresh Prithvisagar Pavan Gollapalli Caroline D'Souza Praveen Rai Iddya Karunasagar Indrani Karunasagar Ballamoole Krishna Kumar Source Type: research
Evaluation of the Averaged Parasympathetic Tone Activity and Its Dynamic Variation to Assess Intraoperative Nociception in Relation to Hemodynamic Changes in Dogs
This study aimed to determine the performance of the averaged parasympathetic tone activity (PTAm) and its dynamic variation (ΔPTA) to assess intraoperative nociception in relation to heart rate (HR) and direct mean arterial pressure (MAP) in dogs undergoing laparoscopic ovariectomy. This prospective, observational, clinical study included 32 bitches. The PTAm, HR, MAP, and bispectral index (BIS) were assessed before (pre-stimulus), as well as 1 min and 2 min after, four surgical stimuli: insufflation, introduction of trocars, and removal of the left and right ovaries. A two-way ANOVA was performed to compare PTAm, HR, MA...
Source: Veterinary Quarterly - July 19, 2023 Category: Veterinary Research Authors: Patricia Ru íz-López Juan Manuel Dom ínguez Juan Morgaz Setefilla Quir ós-Carmona Roc ío Navarrete-Calvo Rafael Jes ús Gómez-Villamandos Jos é Andrés Fernández-Sarmiento M M Granados Source Type: research
Mechanisms of circoviral immunosuppression and pathogenesis with a focus on porcine circovirus 2: a review
Vet Q. 2023 Jul 11:1-28. doi: 10.1080/01652176.2023.2234430. Online ahead of print.ABSTRACTCertain pathogens, due to their adverse effects on the immune reaction, aggravate the course of concomitant heterologous infections. Here we summarize mechanisms by which circoviruses, including the most studied porcine circovirus 2, and other mammalian and avian circoviruses, trigger their own replication and confound the hosts' immune response. At different stages of infection, from latent state to disease induction, these viruses markedly influence the cellular signaling pathways. Circoviruses have been found to interfere with int...
Source: Veterinary Quarterly - July 11, 2023 Category: Veterinary Research Authors: Enik ő Fehér Ferenc Jakab Kriszti án Bányai Source Type: research
