Long non-coding RNA LINC00565 regulates < em > ADAM19 < /em > expression through sponging microRNA-532-3p, thereby facilitating clear cell renal cell carcinoma progression
In conclusion, LINC00565 upregulated ADAM19 via absorbing miR-532-3p, thereby facilitating the progression of ccRCC cells.PMID:38149560 | DOI:10.4103/cjop.CJOP-D-23-00078 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Bin Meng Pengfei Wang Chaofei Zhao Guangwei Yin Xin Meng Lin Li Shengyong Cai Chengquan Yan Source Type: research
Beta-hydroxy-beta-methylbutyrate supplementation preserves fat-free mass in collegiate boxers during acute body mass loss
This study investigated the effect of HMB supplementation on body composition and sport-specific performance in well-trained boxers consuming a hypocaloric diet. Twelve male college boxers were divided into the HMB and placebo (PLA) groups using a body weight-matched single-blind parallel design. The study comprised a 6-day weight loss period (days 1-6), followed by a 3-day competition period (days 7-9). The participants in both the groups consumed 16 kcal/kg/day, including 1.6-1.7 g/kg of carbohydrates, 1.2-1.3 g/kg of protein, and 0.45-0.5 g/kg of fat during the 9-day period. The HMB group consumed 3 g/day HMB. Body comp...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Chen-Kang Chang Shih-Yen Kao Chung-Yuan Wang Source Type: research
Ophiopogonin D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by hydrogen peroxide through Keap1/Nrf2/ARE pathway in diabetes mellitus
In conclusion, OP-D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by H2O2 through activating Keap1/Nrf2/ARE pathway in DM.PMID:38149562 | DOI:10.4103/cjop.CJOP-D-23-00069 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Hongyan Zhang Xuezhi Kang Jun Ruan Li Ma Wenbo Peng Haonan Shang Bing Wang Yongning Sun Source Type: research
Parkin enhances sensitivity of paclitaxel to nasopharyngeal carcinoma by activating BNIP3/NIX-mediated mitochondrial autophagy
This study was performed to explore the possible mechanism of Parkin related to B-cell lymphoma-2 (Bcl-2)/adenovirus E1B 19 kDa interacting protein 3 (BNIP3)/BNIP3-like (NIX)-mediated mitochondrial autophagy in NPC cells. Initially, after Parkin overexpression or silencing, cell viability and proliferation were evaluated by lactate dehydrogenase and colony formation assays. JC-1 staining was used to assess the mitochondrial membrane potential. In addition, the levels of cellular reactive oxygen species (ROS) and mitochondrial ROS were detected using DCFH-DA staining and mitochondrial ROS (MitoSOX) red staining. The express...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Haifeng Ni Renhui Liu Zhen Zhou Bo Jiang Bin Wang Source Type: research
Irbesartan eases lipopolysaccharide-induced lung injury < em > In Vitro < /em > and < em > In Vivo < /em >
Chin J Physiol. 2023 Nov-Dec;66(6):516-525. doi: 10.4103/cjop.CJOP-D-23-00131.ABSTRACTAcute lung injury (ALI) is classified as a devastating pulmonary disorder contributing to significant incidence and fatality rate. Irbesartan (IRB) is an angiotensin II receptor blocker that has been proposed to protect against oleic acid-induced ALI. To this end, the current study is concentrated on ascertaining the role of IRB in ALI and figuring out the probable action mechanism. First, cell counting kit-8 (CCK-8) appraised the viability of human pulmonary microvascular endothelial cells (HPMVECs) exposed to ascending concentrations of...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Zhongyuan Zhang Wei Wang Source Type: research
