Mitochondria in Cancer Stem Cells: From an Innocent Bystander to a Central Player in Therapy Resistance
Stem Cells Cloning. 2023 Aug 23;16:19-41. doi: 10.2147/SCCAA.S417842. eCollection 2023.ABSTRACTCancer continues to rank among the world's leading causes of mortality despite advancements in treatment. Cancer stem cells, which can self-renew, are present in low abundance and contribute significantly to tumor recurrence, tumorigenicity, and drug resistance to various therapies. The drug resistance observed in cancer stem cells is attributed to several factors, such as cellular quiescence, dormancy, elevated aldehyde dehydrogenase activity, apoptosis evasion mechanisms, high expression of drug efflux pumps, protective vascula...
Source: Stem Cells and Cloning: Advances and Applications - August 29, 2023 Category: Stem Cells Authors: Sireesha V Garimella Siri Chandana Gampa Pankaj Chaturvedi Source Type: research