Nasal and Naso-orbito-ethmoid Fractures
Semin Plast Surg DOI: 10.1055/s-0041-1735791Craniofacial fractures are common among trauma patients. Nasal fractures are the most common craniofacial fracture. Understanding how to evaluate and manage craniofacial fractures is important for the craniofacial trauma consultant. This manuscript describes the appropriate workup and management of nasal and naso-orbito-ethmoid fractures. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - September 23, 2021 Category: Cosmetic Surgery Authors: Epstein, Sherise Ettinger, Russell E. Tags: Review Article Source Type: research

Management of Traumatic Soft Tissue Injuries of the Face
Semin Plast Surg DOI: 10.1055/s-0041-1735814Facial soft tissue injuries encompass a broad spectrum of presentations and often present significant challenges to the craniofacial surgeon. A thorough and systematic approach to these patients is critical to ensure that the patient is stabilized, other injuries identified, and the full extent of the injuries are assessed. Initial management focuses on wound cleaning with irrigation, hemostasis, and debridement of nonviable tissue. Definitive management is dependent on the region of the face involved with special considerations for critical structures such as the globe, lacrimal...
Source: Seminars in Plastic Surgery - September 23, 2021 Category: Cosmetic Surgery Authors: Cho, Daniel Y. Willborg, Brooke E. Lu, G. Nina Tags: Review Article Source Type: research

Peripheral Nerve Healing: So Near and Yet So Far
Semin Plast Surg 2021; 35: 204-210 DOI: 10.1055/s-0041-1731630Peripheral nerve injuries represent a considerable portion of chronic disability that especially affects the younger population. Prerequisites of proper peripheral nerve injury treatment include in-depth knowledge of the anatomy, pathophysiology, and options in surgical reconstruction. Our greater appreciation of nerve healing mechanisms and the development of different microsurgical techniques have significantly refined the outcomes in treatment for the past four decades. This work reviews the peripheral nerve regeneration process after an injury, provides an o...
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Baradaran, Aslan El-Hawary, Hassan Efanov, Johnny Ionut Xu, Liqin Tags: Review Article Source Type: research

Bone Healing and Inflammation: Principles of Fracture and Repair
Semin Plast Surg 2021; 35: 198-203 DOI: 10.1055/s-0041-1732334Bones comprise a significant percentage of human weight and have important physiologic and structural roles. Bone remodeling occurs when healthy bone is renewed to maintain bone strength and maintain calcium and phosphate homeostasis. It proceeds through four phases: (1) cell activation, (2) resorption, (3) reversal, and (4) bone formation. Bone healing, on the other hand, involves rebuilding bone following a fracture. There are two main types of bone healing, primary and secondary. Inflammation plays an integral role in both bone remodeling and healing. Therefo...
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: ElHawary, Hassan Baradaran, Aslan Abi-Rafeh, Jad Vorstenbosch, Joshua Xu, Liqin Efanov, Johnny Ionut Tags: Review Article Source Type: research

Radiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options
Semin Plast Surg 2021; 35: 181-188 DOI: 10.1055/s-0041-1731464Radiation therapy is a valuable tool in the treatment of numerous malignancies but, in certain cases, can also causes significant acute and chronic damage to noncancerous neighboring tissues. This review focuses on the pathophysiology of radiation-induced damage and the clinical implications it has for plastic surgeons across breast reconstruction, osteoradionecrosis, radiation-induced skin cancers, and wound healing. The current understanding of treatment modalities presented here include hyperbaric oxygen therapy, autologous fat grafting and stem cells, and ph...
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Nepon, Hillary Safran, Tyler Reece, Edward M. Murphy, Amanda M. Vorstenbosch, Joshua Davison, Peter G. Tags: Review Article Source Type: research

Comparison of Skin Substitutes for Acute and Chronic Wound Management
Semin Plast Surg 2021; 35: 171-180 DOI: 10.1055/s-0041-1731463Chronic and acute wounds, such as diabetic foot ulcers and burns, respectively, can be difficult to treat, especially when autologous skin transplantations are unavailable. Skin substitutes can be used as a treatment alternative by providing the structural elements and growth factors necessary for reepithelialization and revascularization from a nonautologous source. As of 2020, there are 76 commercially available skin substitute products; this article provides a review of the relevant literature related to the major categories of skin substitutes available. [.....
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Bay, Caroline Chizmar, Zachary Reece, Edward M. Yu, Jessie Z. Winocour, Julian Vorstenbosch, Joshua Winocour, Sebastian Tags: Review Article Source Type: research

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications
Semin Plast Surg 2021; 35: 164-170 DOI: 10.1055/s-0041-1731792Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistu...
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Normandin, Shanel Safran, Tyler Winocour, Sebastian Chu, Carrie K. Vorstenbosch, Joshua Murphy, Amanda M. Davison, Peter G. Tags: Review Article Source Type: research

Healing, Inflammation, and Fibrosis
Semin Plast Surg 2021; 35: 140-140 DOI: 10.1055/s-0041-1731743 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Vorstenbosch, Joshua Tags: Preface Source Type: research

Joshua Vorstenbosch, MD, PhD, FRCSC
Semin Plast Surg 2021; 35: 139-139 DOI: 10.1055/s-0041-1731742 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - September 10, 2021 Category: Cosmetic Surgery Authors: Buchanan, Edward P. Tags: Introduction to the Guest Editor Source Type: research

Updates in Diabetic Wound Healing, Inflammation, and Scarring
Semin Plast Surg DOI: 10.1055/s-0041-1731460Diabetic patients can sustain wounds either as a sequelae of their disease process or postoperatively. Wound healing is a complex process that proceeds through phases of inflammation, proliferation, and remodeling. Diabetes results in several pathological changes that impair almost all of these healing processes. Diabetic wounds are often characterized by excessive inflammation and reduced angiogenesis. Due to these changes, diabetic patients are at a higher risk for postoperative wound healing complications. There is significant evidence in the literature that diabetic patients ...
Source: Seminars in Plastic Surgery - July 15, 2021 Category: Cosmetic Surgery Authors: Dasari, Nina Jiang, Austin Skochdopole, Anna Chung, Jayer Reece, Edward Vorstenbosch, Joshua Winocour, Sebastian Tags: Review Article Source Type: research

Tendon: Principles of Healing and Repair
Semin Plast Surg DOI: 10.1055/s-0041-1731632Tendon stores, releases, and dissipates energy to efficiently transmit contractile forces from muscle to bone. Tendon injury is exceedingly common, with the spectrum ranging from chronic tendinopathy to acute tendon rupture. Tendon generally develops according to three main steps: collagen fibrillogenesis, linear growth, and lateral growth. In the setting of injury, it also repairs and regenerates in three overlapping steps (inflammation, proliferation, and remodeling) with tendon-specific durations. Acute injury to the flexor and extensor tendons of the hand are of particular cl...
Source: Seminars in Plastic Surgery - July 15, 2021 Category: Cosmetic Surgery Authors: Chartier, Christian ElHawary, Hassan Baradaran, Aslan Vorstenbosch, Joshua Xu, Liqin Efanov, Johnny Ionut Tags: Review Article Source Type: research

Current Advances in Hypertrophic Scar and Keloid Management
Semin Plast Surg DOI: 10.1055/s-0041-1731461Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury due to local fibroblast proliferation and collagen overproduction. This response occurs because of pathologic wound healing due to dysregulation in the inflammatory, proliferative, and/or remodeling phase. Patients with hypertrophic scars or keloids report reduced quality of life, physical status, and psychological health. Hypertrophic scars or keloids will develop in 30 to 90% of individuals, and despite their prevalence, treatment remains a challenge. Of the treatments currently available fo...
Source: Seminars in Plastic Surgery - July 15, 2021 Category: Cosmetic Surgery Authors: Barone, Natasha Safran, Tyler Vorstenbosch, Joshua Davison, Peter Cugno, Sabrina Murphy, Amanda Tags: Review Article Source Type: research

Wound Healing: A Comprehensive Review
Semin Plast Surg DOI: 10.1055/s-0041-1731791Wound healing is an intricate, tightly regulated process that is critical to maintaining the barrier function of skin along with preserving all other skin functions. This process can be influenced by a variety of modifiable and nonmodifiable factors. As wound healing takes place in all parts of the human body, this review focuses on cutaneous wound healing and highlights the classical wound healing phases. Alterations in any of these phases can promote chronic wound development and may impede wound healing. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New...
Source: Seminars in Plastic Surgery - July 15, 2021 Category: Cosmetic Surgery Authors: Almadani, Yasser H. Vorstenbosch, Joshua Davison, Peter Murphy, Amanda Tags: Review Article Source Type: research

Current Concepts in Capsular Contracture: Pathophysiology, Prevention, and Management
Semin Plast Surg DOI: 10.1055/s-0041-1731793Over 400,000 women in the United States alone will have breast implant surgery each year. Although capsular contracture represents the most common complication of breast implant surgery, surgeons continue to debate the precise etiology. General agreement exists concerning the inflammatory origin of capsular fibrosis, but the inciting events triggering the inflammatory cascade appear to be multifactorial, making it difficult to predict why one patient may develop capsular contracture while another will not. Accordingly, researchers have explored many different surgical, biomateria...
Source: Seminars in Plastic Surgery - July 13, 2021 Category: Cosmetic Surgery Authors: Safran, Tyler Nepon, Hillary Chu, Carrie K. Winocour, Sebastian Murphy, Amanda Davison, Peter Dionisopolos, Tassos Vorstenbosch, Joshua Tags: Review Article Source Type: research

When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation
Semin Plast Surg DOI: 10.1055/s-0041-1731462Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new t...
Source: Seminars in Plastic Surgery - July 6, 2021 Category: Cosmetic Surgery Authors: Conlon, Christopher Pupa, Lauren Reece, Edward M. Chu, Carrie K. Yu, Jessie Z. Vorstenbosch, Joshua Winocour, Sebastian Tags: Review Article Source Type: research