Bone Grafts, Bone Substitutes, and Orthobiologics: Applications in Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 190-199 DOI: 10.1055/s-0039-1693020As reconstructive needs often extend past the soft tissue alone, a plastic surgeon must also be well versed in the methods of bony reconstruction. Understanding of the basic science of fracture healing and the biochemical mechanisms of the different bone grafts, bone substitutes, and orthobiologics is essential to selecting among the many different options available to the modern plastic surgeon. This review provides a broad overview of these different options and the specific applications for plastic surgeons based on anatomic location. [...] Thieme ...
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Raghuram, Anjali Singh, Aspinder Chang, Daniel K. Nunez, Mervin Reece, Edward M. Tags: Review Article Source Type: research

The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications
This article reviews the basic science of Integra and provides an overview of the many expanding applications based on anatomic location. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Chang, Daniel K. Louis, Matthew R. Gimenez, Alejandro Reece, Edward M. Tags: Review Article Source Type: research

Acellular Dermal Matrices: Applications in Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 173-184 DOI: 10.1055/s-0039-1693019Modern advances in tissue engineering have transformed the plastic surgeon's management strategies across a wide variety of applications. Comprehension of the fundamentals of biologic constructs is critical to navigating the available armamentarium. It is essential that plastic surgeons become familiar with some of the existing methods for utilizing biologics as well as the advantages and limitations to their use. In this article, the authors describe the basic science of biologics with a focus on acellular dermal matrices (ADMs), and review the recen...
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Tork, Shahryar Jefferson, Ryan C. Janis, Jeffrey E. Tags: Review Article Source Type: research

The Evolving Landscape of Gene Therapy in Plastic Surgery
This article aims to provide an overview of the fundamentals of gene therapy and discuss future potential interventions relevant to plastic surgeons. These interventions include enhancing tissue regeneration and healing, as well as modifying disease processes in congenital anomalies. Though clinical applications are still on the horizon, a deeper understanding of these new advances will help plastic surgeons understand the current landscape of gene therapy and stay abreast of future opportunities. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |...
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Raghuram, Anjali Singh, Aspinder Chang, Daniel K. Nunez, Mervin Reece, Edward M. Schultz, Brent E. Tags: Review Article Source Type: research

Stem Cells and Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 162-166 DOI: 10.1055/s-0039-1693018Pluripotent stem cells can help recreate a variety of different tissues. Stem cells are already in use in a variety of ways in the medical field but plastic surgeons have particular interest because of the constant need to produce additional tissue or mold existing tissue. More and more commercial products are being marketed with far-reaching goals and some with proven and promising results. In this article, the authors discuss the basic science behind stem cells and the theories on how they work. They then discuss some active uses of stem cells that ...
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Agrawal, Nikhil A. Zavlin, Dmitry Louis, Matthew R. Reece, Edward M. Tags: Review Article Source Type: research

Platelet-Rich Plasma: Principles and Applications in Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 155-161 DOI: 10.1055/s-0039-1693400Platelet-rich plasma (PRP) is an autogenously harvested liquid platelet concentrate extracted from a patient's peripheral blood that contains higher than baseline concentrations of growth factors and cytokines. This innovative new technology has demonstrated great promise in the field of plastic surgery, and its use has been evaluated in several clinical settings including wound healing, hair restoration, and skin rejuvenation. The goal of this article is to explain the biology behind PRP and to review the basic principles involved in its preparation....
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Abu-Ghname, Amjed Perdanasari, Aurelia Trisliana Davis, Matthew J. Reece, Edward M. Tags: Review Article Source Type: research

Principles and Applications of Fat Grafting in Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 147-154 DOI: 10.1055/s-0039-1693438Autologous fat transplantation has become increasingly popular in recent years. Its biocompatable properties and availability made it a widely used treatment modality for soft tissue augmentation and volume replacement in both reconstructive and aesthetic plastic surgery. Multiple protocols and clinical applications have been described in the literature, with wide variations in the harvesting, processing, and injection techniques. In this review, the authors will discuss the basic principles and clinical applications of fat grafting in plastic and rec...
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Abu-Ghname, Amjed Perdanasari, Aurelia Trisliana Reece, Edward M. Tags: Review Article Source Type: research

Biologics in Plastic Surgery
Seminars in Plastic Surgery 2019; 33: 145-146 DOI: 10.1055/s-0039-1693434 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Reece, Edward M. Tags: Preface Source Type: research

Edward M. Reece, MD, MBA
Seminars in Plastic Surgery 2019; 33: 143-144 DOI: 10.1055/s-0039-1693433 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Plastic Surgery)
Source: Seminars in Plastic Surgery - August 1, 2019 Category: Cosmetic Surgery Authors: Hollier, Larry H. Tags: Introduction to the Guest Editor Source Type: research

Complications and Treatment of Delayed or Inadequately Treated Nasoorbitoethmoid Fractures
Seminars in Plastic Surgery 2019; 33: 138-142 DOI: 10.1055/s-0039-1685474Delayed or improper repair of nasoorbitoethmoid (NOE) fractures can lead to debilitating outcomes including diplopia, epiphora, nasal obstruction, facial asymmetry, and poor cosmesis. As such, NOE fractures should be repaired promptly and properly to prevent these unwanted sequelae. Treating patients with delayed, untreated, or inadequately reduced NOE fractures is challenging due to scarring and contracture. Saddle nose deformity, telecanthus, enophthalmos, nasolacrimal duct obstruction, and soft-tissue scarring are often encountered in the secondary...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Han, Peter S. Kim, Yohanan Herford, Alan S. Inman, Jared C. Tags: Review Article Source Type: research

Prosthetic Reconstruction of Orbital Defects
Seminars in Plastic Surgery 2019; 33: 132-137 DOI: 10.1055/s-0039-1685479Orbital and craniomaxillofacial defects, in general, are best approached preoperatively by a multidisciplinary team with a clear reconstructive plan in place. Orbital defects result from a myriad of underlying diseases and injuries, and reconstruction after orbital evisceration, enucleation, or exenteration can pose a challenge to the reconstructive team. Reconstruction of orbital injuries with orbital implants and prostheses can lead to acceptable aesthetic outcomes, and the reconstructive surgeon should be familiar with current orbital implants and ...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Vincent, Aurora Kohlert, Scott Kadakia, Sameep Sawhney, Raja Ducic, Yadranko Tags: Review Article Source Type: research

Soft Tissue Microvascular Reconstruction of Orbital Exenteration Defects
Seminars in Plastic Surgery 2019; 33: 125-131 DOI: 10.1055/s-0039-1685480The main goal of head and neck reconstruction is the restoration of form and function. Oncologic surgery makes this process more complex, as the preplanned defect can be very different from its intraoperative counterpart. This emphasizes the role of preoperative planning and a diverse reconstructive “tool box” that can accommodate a variety of complicated defects. The other reconstructive goals are determined by the patient with the aid of an interdisciplinary team. While multiple local and regional reconstructive options are available, free tissu...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Badhey, Arvind Haidar, Yarah Genden, Eric Tags: Review Article Source Type: research

Regional Reconstruction of Orbital Exenteration Defects
Seminars in Plastic Surgery 2019; 33: 120-124 DOI: 10.1055/s-0039-1685475Aggressive disease such as invasive fungal infections or malignancies may necessitate orbital exenteration. The defects of orbital exenteration are often complex involving adjacent structures. Rehabilitation of the orbital exenteration defect poses unique challenges to the reconstructive surgeon. Various options have been described ranging from secondary intention to microvascular free tissue reconstruction. Here the authors review local/regional options for reconstruction of orbital exenteration defects. [...] Thieme Medical Publishers 333 Seventh Av...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Jategaonkar, Ameya A. Vernon, Dominic Byrne, Patrick J. Tags: Review Article Source Type: research

Orbitocranial Approaches to the Skull Base
Seminars in Plastic Surgery 2019; 33: 114-119 DOI: 10.1055/s-0039-1685478There are a myriad of approaches and surgical options for removal and treatment of skull base diseases. While, historically, large open approaches have been preferred, several endoscopic and minimally invasive techniques are now available that preserve intraoperative visualization and surgical success while minimizing morbidity and recovery times. Herein, the authors review common open, minimally invasive, and endoscopic approaches to the anterior skull base. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Vincent, Aurora Wang, Weitao Sokoya, Mofiyinfolu Kadakia, Sameep Chan, David Ducic, Yadranko Tags: Review Article Source Type: research

Orbital Trauma
Seminars in Plastic Surgery 2019; 33: 106-113 DOI: 10.1055/s-0039-1685477The orbit is contained within a complex bony architecture with overlying soft tissue that involves many important anatomical structures. Orbital trauma is a frequent cause of damage to these structures. The authors review the literature on reconstructive techniques focusing on fractures of the orbital rim, orbital roof, orbital floor, medial orbital wall, and naso-orbito-ethmoid complex. A thorough literature review was conducted using PubMed analyzing articles relevant to the subject matter. Various search terms were used to identify articles regardi...
Source: Seminars in Plastic Surgery - April 25, 2019 Category: Cosmetic Surgery Authors: Lozada, Kirkland N. Cleveland, Patrick W. Smith, Jesse E. Tags: Review Article Source Type: research