Raman spectroscopic analysis of High Molecular Weight Proteins in solution – considerations for sample analysis and data pre-processing
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01701H, PaperDrishya Rajan Parachalil, Brenda Brankin, Jennifer McIntyre, Hugh Byrne Analysis of proteins present in the blood stream can potentially deliver crucial information on patient health and indicate the presence of numerous pathologies. Current analytical techniques can, however, be costly... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Drishya Rajan Parachalil Source Type: research

Graphene, electrospun and granular activated carbon membranes for eliminating heavy metals, pesticides and bacteria in water and wastewater treatment processes.
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN00922H, Critical ReviewPiumie Rajapaksha, Shaneel Chandra, Aoife Power, James Chapman The availability of safe water has an significant impact on all parts of society, its growth and sustainability, both politically and socioeconomically. Consequently, the preservation of water and wastewater treatment... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Piumie Rajapaksha Source Type: research

Logical MS/MS Scans: A New Set of Operations for Tandem Mass Spectrometry
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01661E, PaperDalton Thomas Snyder, Lucas Szalwinski, Mitch Wells, R Graham Cooks A new set of operations for tandem mass spectrometry in a linear ion trap is described. Logical MS/MS operations categorize compounds in mixtures based on characteristic structural features as revealed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Dalton Thomas Snyder Source Type: research

Investigations on the Interface of Nucleic Acid Aptamers and Binding Targets
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01467A, MinireviewShundong Cai, Jian hua Yan, hongjie xiong, Yanfei Liu, Dongming Peng, Zhenbao Liu Nucleic acid aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can specifically bind to target molecules via formed three-dimensional structures, which have attracted substantial scientific interest.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Shundong Cai Source Type: research

Sensor Arrays Made by Self-Organized Nanoreceptors for Detection and Discrimination of Carboxylate Drugs
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01756E, PaperXiaohuan Sun, Ping Liu, Fabrizio Mancin Nanoreceptors capable of recognizing amphiphilic organic carboxylates have been obtained by exploiting the self-organization properties of monolayer protected gold nanoparticles. Affinity and selectivity for the target compounds can be modulated... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Xiaohuan Sun Source Type: research

Fabrication of 3D continuous-flow reverse-transcription polymerase chain reaction microdevice integrated with on-chip fluorescence detection for semi-quantitative assessment of gene expression
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01739E, PaperQuang Nghia Pham, Kieu The Loan Trinh, Nguyen Khoi Song Tran, Tae sik Park, Nae Yoon Lee We fabricate a three-dimensional (3D) microdevice operated with minimal peripheral accessories, including a portable pump for semi-automated sample delivery and a single heater for temperature control, for performing reverse transcription... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Quang Nghia Pham Source Type: research

Single-Molecule DNA Visualization Using AT-specific Red and Non-specific Green DNA-Binding Fluorescent Proteins
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01426D, PaperKyubong Jo, Jihyun Park, Seunghyun Lee, Nabin Won, Eunji Shin, Soo-hyun Kim, Min-young Chun, Jungyeun Gu, Gun Young Jung, Kwang-il Lim The recent advances in the single cell genome analysis are generating a considerable amount of novel insights into complex biological systems. However, there are still technical challenges because each cell... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 8, 2018 Category: Chemistry Authors: Kyubong Jo Source Type: research

Qualitative analysis of antibody –drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Malin K ällsten, Rafael Hartmann, Konstantin Artemenko, Sara Bergström Lind, Fredrik Lehmann, Jonas Bergquist Four different cysteine linked antibody-drug conjugates (ADCs) consisting of Trastuzumab-vc-MMAE were analysed with four common analytical techniques with respect to drug-to-antibody ratio (DAR) and molecular weight. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 6, 2018 Category: Chemistry Authors: Malin K ällsten Source Type: research

Dual purpose fibre – SERS pH sensing and bacterial analysis
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Holly Fleming, Sarah McAughtrie, Bethany Mills, Michael G. Tanner, Angus Marks, Colin J. Campbell A way to incorporate SERS nanosensors on the end of an optical fibre that also allows for the extraction of bacterial samples. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 6, 2018 Category: Chemistry Authors: Holly Fleming Source Type: research

A G-triplex based molecular beacon for label-free fluorescence “turn-on” detection of bleomycin
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01208C, PaperLin Ma, Xue Han, Lian Xia, Rong-Mei Kong, Fengli Qu A facile and label-free G-triplex based molecular beacon (G3MB) sensing system was constructed for fluorescence “turn-on” detection of BLM. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Lin Ma Source Type: research

Green, fast, and large-scale synthesis of highly fluorescent Au nanoclusters for Cu2+ detection and temperature sensing
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01617H, PaperYunxiao Jia, Tianxia Sun, Yingnan Jiang, Weiyi Sun, Yu Zhao, Jingwei Xin, Yiting Hou, Wensheng Yang A rapid sonochemical route is used for green, fast, and large-scale synthesis of highly fluorescent Au nanoclusters for Cu2+ and temperature sensing. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yunxiao Jia Source Type: research

Highly sensitive and multiplexed miRNA analysis based on digitally encoded silica microparticles coupled with RCA-based cascade amplification
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01393D, PaperShengquan Liu, Han Fang, Chengjiao Sun, Nana Wang, Jiong Li Multiple miRNA sensitive analysis by coupling digitally encoded silica microparticles with RCA-based cascade amplification. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Shengquan Liu Source Type: research

A ratiometric fluorescent BODIPY-based probe for rapid and highly sensitive detection of cysteine in human plasma
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01438H, PaperNannan Wang, Yue Wang, Jinhua Gao, Xin Ji, Jinling He, Jian Zhang, Weili Zhao Biological thiols, especially low molecular weight thiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) occupied a pivotal role in physiological and pathological sysems. Thus, the detection of biothiols is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Nannan Wang Source Type: research

How to Unravel the Chemical Structure and Component Localization of Individual Drug-Loaded Polymeric Nanoparticles by Using Tapping AFM-IR
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01239C, PaperJeremie Mathurin, Elisabetta Pancani, Ariane Deniset, Kevin Kjoller, Craig Prater, Ruxandra Gref, Alexandre dazzi AFM-IR is a photothermal technique which combines AFM and infrared (IR) spectroscopy to unambiguously identify the chemical composition of a sample with tens of nanometer spatial resolution. So far, it... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Jeremie Mathurin Source Type: research

Hyphenation of High-Temperature Liquid Chromatography with High-Pressure Electrospray Ionization for Subcritical Water LC-ESI-MS
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01113C, PaperLee Chuin Chen, Tsubasa Naito, Satoshi Ninomiya, Kenzo Hiraoka High-pressure electrospray ionization (HP-ESI) performed under super-atmospheric pressure allows a stable and efficient electrospray of pure aqueous and/or superheated solutions even under μL/min flow rate regime. In this paper, we... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Lee Chuin Chen Source Type: research

Solvent directed Selective and sensitive Fluorescent detection of target ions using a coumarin-pyridine probe
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01736K, PaperYiting Xie, Wenjing Cheng, Bing Jin, Chaogen Liang, Yubin Ding, Wei-Hua Zhang The developments of fluorescent probes to selectively and sensitively detect more than one target analytes in a given condition is a challenging task due to the lack of designing strategies.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yiting Xie Source Type: research

A Near-Infrared Xanthene Fluorescence Probe for Monitoring Peroxynitrite in Living Cells and Mouse Inflammation Model
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01107A, PaperYongquan Wu, Aiping Shi, Yuanyan Li, Hong Zeng, Xiaoyong Chen, Jie Wu, Xiaolin Fan Peroxynitrite (ONOO −) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO−... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yongquan Wu Source Type: research

A triazine-based conjugated microporous polymer composite for magnetic solid phase extraction of 5-nitroimidazoles coupled with UPLC-MS/MS for quantitation
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01600C, PaperWei Yang, Xia Wu, Tingting Liu, Ting Wang, Xiaohong Hou Attractive triazine-based conjugated microporous polymer (TCMP) was fabricated via Friedel-Crafts reaction and magnetized with a simple reduction co-precipitation method for the first time. The morphology and textural properties of the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Wei Yang Source Type: research

Improved ATR-FTIR Detection of Hydrocarbons in Water with Semi-Crystalline Polyolefin Coatings on ATR Elements
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01280F, PaperChangwoo Nam, Tawanda James Zimudzi, Richard Adam Wiencek, T.C. Mike Chung, Michael Hickner In situ measurement of hydrocarbons in water is critical for assuring the safety and quality of drinking water and in environmental remediation activities such as the cleanup of oil spills.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Changwoo Nam Source Type: research

Raman spectroscopy as a novel tool for fast characterization of perivascular adipose tissue chemical composition
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01307A, PaperKrzysztof Czamara, Zuzanna Majka, Aleksandra Fus, Kamila Matjasik, Marta Zofia Pacia, Magdalena Sternak, Stefan Chlopicki, Agnieszka Kaczor One of the new targets of untapped therapeutic potential is the perivascular adipose tissue (pVAT). pVAT releases a plethora of pro- and anti-inflammatory agents and is involved in the inflammatory... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Krzysztof Czamara Source Type: research

An ultrasensitive electrochemical cytosensor for highly specific detection of HL-60 cancer cells based on metal ion functionalized titanium phosphate nanospheres
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01327F, PaperPanpan Sun, Wei-Wei Xiong, Dong Zhu, Zhuhua Dong, Xuping Jin, Beibei Liu, Yi Zhang, Beihua Bao, Weifeng Yao, Li Zhang, Fang-Fang Cheng An ultrasensitive cytosensor was constructed using KH1C12 aptamers as cell capturers and Cd2+-exchanged titanium phosphate nanospheres as electrochemical probes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Panpan Sun Source Type: research

Flexible Construction of Cellulose Photonic Crystal Optical Sensing Nano-materials Detecting Organic Solvents
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01236A, PaperDan Yan, Renbin Li, Wei Lu, Chunmei Piao, Lili Qiu, Zi-hui Meng, Shushan Wang We developed a simple and efficient method to construct 3D and 2D opal and inverse opal cellulose photonic crystal films (CPCF) by embedding 3D or 2D polymethyl methacrylate (PMMA) colloidal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Dan Yan Source Type: research

G-triplex based molecular beacon for label-free fluorescence “turn-on” detection of bleomycin
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01208C, PaperLin Ma, Xue Han, Lian Xia, Rong-Mei Kong, Fengli Qu Since the bleomycins (BLMs) play a prominent role in the clinical treatment of various cancers, the development of convenient and sensitive detection assays for BLM is of great significance in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Lin Ma Source Type: research

A PCR-free technology to detect and quantify microRNAs directly from human plasma
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01397G, CommunicationAntonio Mar ín Romero, Agustín Robles Remacho, Mavys Tabraue-Chávez, Rosario María Sánchez-Martín, Juan José Guardia Monteagudo, Mario Antonio Fara, Francisco Javier López-Delgado, Salvatore Pernagallo, Juan J. Diaz-Mochon A novel sensitive, specific and rapid method for the detection and quantification of microRNAs without requiring extraction from their biological sources is now available using a novel chemical based, PCR-free... The content of this RSS Feed (c) The Royal Society of Chemistry (...
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Antonio Mar ín Romero Source Type: research

Electrochemical aptasensors for zeatin detection based on MoS2 nanosheets and enzymatic signal amplification
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01356J, PaperYunlei Zhou, Huanshun Yin, Yue Wang, Chengji Sui, Minghui Wang, Shiyun Ai A simple and sensitive electrochemical aptasensor was constructed for zeatin detection, which is based on the block of the formation of Y-shape DNA due to the formation of the conjugate of zeatin and its aptamer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yunlei Zhou Source Type: research

Determination of the illegal adulteration of natural healthcare products with chemical drugs using surface-enhanced Raman scattering
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01286E, PaperJiawei Wu, Lixia Zhang, Xiangfeng Bu, Peng Li, Bing Zhao, Yuan Tian Silver nanoparticles stabilized using sodium alginate were synthesized as SERS substrate to determine vardenafil and rosiglitazone maleate based on the coffee ring effect. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Jiawei Wu Source Type: research

A novel fluorescent probe with red emission and a large Stokes shift for selective imaging of endogenous cysteine in living cells
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01657G, PaperDugang Chen, Zi Long, Yecheng Dang, Li Chen Cysteine (Cys) plays crucial roles in physiological and pathological processes, which is related to many diseases. To selectively monitor Cys over its analogues homocysteine (Hcy) and glutathione (GSH) is of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Dugang Chen Source Type: research

A Sensitive and Low background Fluorescent Sensing Strategy Based on g-C3N4-MnO2 Sandwich Nanocomposite and Liposome Amplification for Ricin Detection
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01217B, PaperChen Men, Chun Hong Li, Xue Mei Wei, Jia Jun Liu, Yu Xin Liu, Cheng Zhi Huang, Shu Jun Zhen Ricin is an extremely potent ribosomal inactivating protein and serve as a likely food biocontaminant or biological weapon. Thus, simple, sensitive and accurate analytical assays capable of detecting ricin are... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Chen Men Source Type: research

A facile AuNPs@aptamer-modified mercaptosiloxane-based hybrid affinity monolith with an unusually high coverage density of aptamer for on-column selective extraction of ochratoxin A
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01531G, PaperJinxin Chi, Maolin Chen, Lijun Deng, Xucong Lin, Zenghong Xie A facile AuNP@aptamer-modified affinity monolith was fabricated with unusually high coverage density of aptamers for on-column high-sensitivity extraction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Jinxin Chi Source Type: research

NIR two-photon fluorescent probe for biothiol detection and imaging of living cells in vivo
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01605D, PaperXiang Xia, Ying Qian A fluorescence probe,Cz-BDP-NBD, for detecting biothiols with two photon excited fluorescence has been designed and used under irradiation from sapphire pulsed lasers at 800 nm. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Xiang Xia Source Type: research

Pushing the limits of detection for proteins secreted from single cells using quantum dots
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01083H, PaperVanessa Herrera, Ssu-Chieh Joseph Hsu, Maha K. Rahim, Carol Chen, Lisa Nguyen, Wendy F. Liu, Jered B. Haun Single cell secretion studies have provided valuable insight into population heterogeneity, but low detection sensitivity requires cells to secrete thousands of molecules. We employed semiconductor quantum dots and a new single particle imaging approach to improve detection sensitivity to only a few secreted molecules per cell. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Roya...
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Vanessa Herrera Source Type: research

Analysis of soluble or titanium dioxide derived titanium levels in human whole blood: consensus from an inter-laboratory comparison
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN00824H, PaperDagmar Koller, Paul Bramhall, J érôme Devoy, Heidi Goenaga-Infante, Chris F. Harrington, Elizabeth Leese, Jackie Morton, Susana Cuello, Joanne Rodgers, Barry Sampson, Jonathan Joseph Powell Exposure to titanium (Ti), via the ingestion of pigment grade Ti dioxide (TiO2), is commonplace for Westernised populations. It may also occur as a consequence of metal ion leaching in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Dagmar Koller Source Type: research

Fluid-permeable enzymatic lactate sensors for micro-volume specimen
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN00979A, PaperHiroyuki Kai, Yuto Kato, Ryoma Toyosato, Matsuhiko Nishizawa Sensing of lactate in perspiration provides a way to monitor health and control exercise. The volume of perspiration is miniscule, and the efficient collection of perspiration is desired for its... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Hiroyuki Kai Source Type: research

Advancing single-cell proteomics and metabolomics with microfluidic technologies
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01503A, Critical ReviewJian Liu, Yifan Liu, Xuyue Chen, Yiqiu Zhang Recent advances in single-cell analysis have unraveled substantial heterogeneity among seemingly identical cells at genomic and transcriptomic level. These discoveries have urged scientists to develop new tools that are capable... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Jian Liu Source Type: research

Correction: The mechanism and regularity of quenching the effect of bases on fluorophores: the base-quenched probe method
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Huihui Mao, Guanghua Luo, Yuxia Zhan, Jun Zhang, Shuang Yao, Yang Yu To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Huihui Mao Source Type: research

Lectin inspired polymers based on the dipeptide Ser-Asp for glycopeptide enrichment
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.B. Zhang, R. Z. Yu, Y. H. Yu, C. Peng, R. Xie, Y. Zhang, J. Y. Chen Lectin inspired polymers polySD-SiO2 were prepared and applied to the high-efficiency enrichment of glycopeptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: B. Zhang Source Type: research

Accurate Microfluidic Immunoassay of CD62L in Bladder Cancer Serum Samples
We report a low-cost, sensitive, bead-based electrochemical immunoarray for soluble L-selectin (or CD62L protein), a potential biomarker for staging bladder cancer. We used a semi-automated modular microfluidic array with online... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: James Rusling Source Type: research

Continuous droplet electroporation system for high throughput processing
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01259H, PaperBeyong Sun Yoo, Do Jin Im, Myung Mo Ahn, Sung Jin Park, Yeong Hun Kim, Taewoong Um, In Seok Kang A continuous droplet electroporation (EP) system capable of handling a billion cells has been proposed and demonstrated using a proof-of-concept prototype design. Numerical simulations were conducted to design the new... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Beyong Sun Yoo Source Type: research

Interaction study of cancer cells and fibroblasts on a spatially confined oxygen gradient microfluidic chip to investigate the tumor microenvironment
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01216D, PaperWei Sun, Yuqing Chen, Yuerong Wang, Pei Luo, Min Zhang, Hongyang Zhang, Ping Hu This paper reports a single-layered microfluidic device for studying the interaction of cancer cells and fibroblasts in an oxygen gradient. By using a spatially confined oxygen scavenging chemical reaction, the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Wei Sun Source Type: research

In vivo measurement of the dynamics of norepinephrine in an olfactory bulb following ischemia-induced olfactory dysfunction and its responses to dexamethasone treatment
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01300D, PaperYinghong Zhang, Lijuan Li, Tao Li, Ying Xin, Junxiu Liu, Furong Ma, Lanqun Mao Information on the dynamics of molecules following olfactory dysfunction remains essential for understanding the molecular events involved in the pathological process of olfactory dysfunction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yinghong Zhang Source Type: research

Rapid determination of binding parameters of chitin binding domains using chitin-coated quartz crystal microbalance sensor chips
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01453A, PaperStephan Vogt, Marco Kelkenberg, Tanja N öll, Benedikt Steinhoff, Holger Schönherr, Hans Merzendorfer, Gilbert Nöll Chitin present in fungal cell walls has been considered as a diagnostic polymer for the detection of fungal infections. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Stephan Vogt Source Type: research

High throughput single cell separation and identification using Self-priming Isometric and Equant Screw valve-based (SIES) microfluidic chip
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01464G, PaperYing Mu, Jiumei Hu, Yanan Xu, Tong Gou, Shufang Zhou Abstract The emergence of various single cell separation and identification platforms has greatly promoted the development of single cell research. Among these platforms, microfluidic chip-based strategies occupy a significant position... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Ying Mu Source Type: research

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01108G, PaperSang-Yong Lee, xihuan luo, Vigneshwaran Namasivayam, Jennifer Geiss, Salahuddin Mirza, Julie Pelletier, Holger Stephan, Jean Sevigny, Christa E Muller Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5 ’-nucleotidase (CD73) to immunosuppressive adenosine. Activation of CD39... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Sang-Yong Lee Source Type: research

An “off-on” phosphorescent aptasensor for the detection of thrombin based on PRET
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01571F, PaperYan Xiong, Meiyu Liang, Yue Cheng, Jiarui Zou, Yan Li Thrombin plays an important role in the blood coagulation cascadend and it stimulates the process of platelet aggregation. Herein, we developed a highly efficient and sensitive phosphorescent aptasensor system for... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yan Xiong Source Type: research

Ratiometric red-emission fluorescence detection of Al3+ in pure aqueous solution and live cells by a fluorescent peptidyl probe using aggregation-induced emission
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01221K, PaperLok Nath Neupane, Pramod Kumar Mehta, Semin Oh, See-Hyoung Park, Keun-Hyeung Lee A novel peptidyl probe using aggregation induced emission was proposed for the selective ratiometric detection of Al3+ ions in pure aqueous solutions and live cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Lok Nath Neupane Source Type: research

A novel electrochemical immunoassay for carcinoembryonic antigen based on glucose oxidase-encapsulated nanogold hollow spheres with a pH meter readout
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01436A, PaperYu Jiang, Zhiying Su, Jian Zhang, Meijiao Cai, Lili Wu A portable electrochemical immunosensor was designed for the detection of CEA on a pH meter by using glucose oxidase-encapsulated gold hollow microspheres for signal amplification. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Yu Jiang Source Type: research

Exonuclease III-assisted multiple cycle amplification for the sensitive detection of DNA with zero background signal
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01365A, PaperWen-Jing Liu, Qinfeng Xu, Fei Ma, Chen-Chen Li, Chun-Yang Zhang We demonstrate the development of Exo III-assisted multiple cycle amplification for the sensitive detection of DNA with zero background signal. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Wen-Jing Liu Source Type: research

A Novel Mitochondrial-Targeting Near-Infrared Fluorescence Probe for Imaging γ-Glutamyl Transpeptidase Activity in Living Cells
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01460D, PaperHai-Juan Liu, Feng Liu, Fenglin Wang, Ruqin Yu, Jian-Hui Jiang γ-Glutamyl transpeptidase (GGT) plays an essential role in regulating cellular glutathione and cysteine homeostasis, and its abnormal elevation is associated with different diseases including cancers. Here a novel mitochondrial-targeting near-infrared... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Hai-Juan Liu Source Type: research

Detection of opium alkaloids in a Cypriot base-ring juglet
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Rachel K. Smith, Rebecca J. Stacey, Ed Bergstr öm, Jane Thomas-Oates The first rigorous chemical evidence supporting the controversial theory linking Bronze Age Cypriot base-ring juglets with the opium poppy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: Rachel K. Smith Source Type: research

Human-level blood cell counting on lens-free shadow images exploiting deep neural networks
Analyst, 2018, Advance Article DOI: 10.1039/C8AN01056K, PaperDaeHan Ahn, JiYeong Lee, SangJun Moon, Taejoon Park In-line holographic microscopes paved the way for realizing portable cell counting systems using deep neural networks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - October 5, 2018 Category: Chemistry Authors: DaeHan Ahn Source Type: research