Reproduction, Fertility, and Development This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

From fertilised oocyte to cultivated meat - harnessing bovine embryonic stem cells in the cultivated meat industry
Reprod Fertil Dev. 2023 Dec;36(2):124-132. doi: 10.1071/RD23169.ABSTRACTGlobal demand for animal protein is on the rise, but many practices common in conventional production are no longer scalable due to environmental impact, public health concerns, and fragility of food systems. For these reasons and more, a pressing need has arisen for sustainable, nutritious, and animal welfare-conscious sources of protein, spurring research dedicated to the production of cultivated meat. Meat mainly consists of muscle, fat, and connective tissue, all of which can be sourced and differentiated from pluripotent stem cells to resemble the...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Eldar Zehorai Ayelet Maor-Shoshani Natali Molotski Anastasya Dorojkin Nitzan Marelly Tami Dvash Neta Lavon Source Type: research

The oocyte: the key player in the success of assisted reproduction technologies
Reprod Fertil Dev. 2023 Dec;36(2):133-148. doi: 10.1071/RD23164.ABSTRACTThe ovulation of a mature oocyte at metaphase II of meiosis, with optimal potential to undergo fertilisation by a sperm cell, complete meiosis and sustain the switch to mitotic division, and support early embryo development, involves a protracted and disrupted/delayed series of processes. Many of these are targeted for exploitation in vivo , or recapitulation in vitro , by the livestock industry. Reproductive technologies, including AI, multiple ovulation embryo transfer, ovum pick-up, in vitro embryo production, and oestrus and ovulation synchronisati...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Trudee Fair Pat Lonergan Source Type: research

Paternal determinants of early embryo development
Reprod Fertil Dev. 2023 Dec;36(2):43-50. doi: 10.1071/RD23172.ABSTRACTExisting research has primarily focused on investigating the impacts of the maternal environment, female fertility phenotype, and genetics on pregnancy loss in dairy cattle. Recently, attention has been directed toward understanding the role the sire has on embryo quality and viability. Studies have shown there is a paternal influence on early pregnancy loss, but the specific mechanisms impacting pregnancy establishment and maintenance remain unclear. Despite clear differences that sires have on pregnancy outcomes, there is a lack of evidence regarding s...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Kelsey N Lockhart Lindsey C Fallon M Sofia Ortega Source Type: research

How I overcame problems in < em > in vitro < /em > fertilisation of livestock animals
Reprod Fertil Dev. 2023 Dec;36(2):27-33. doi: 10.1071/RD23162.ABSTRACTIn my research life of 35years, growing with IETS as a researcher of in vitro maturation and fertilisation (IVM/IVF) of porcine and cattle oocytes, I suffered from hard times related to solving problems that prevented the progress of my research and conferment of my degrees. Many researchers may have similar problems. Thus, I would like to address a few examples of how I overcame these problems related to IVF and help young researchers with similar troubles. There were four main problems to be solved in my experiments. Problem 1: Establishment of IVF usi...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Takashi Nagai Source Type: research

Production of light-coloured, low heat-absorbing Holstein Friesian cattle by precise embryo-mediated genome editing
CONCLUSIONS: Although biopsy screening was not absolutely accurate, non-mosaic, precisely edited calves can be readily produced by embryo-mediated editing. The lighter coat colouring caused by the PMEL mutation can lower radiative heat gain which might help to reduce heat stress.IMPLICATIONS: The study validates putative causative sequence variants to rapidly adapt grazing cattle to changing environmental conditions.PMID:38064192 | DOI:10.1071/RD23163 (Source: Reproduction, Fertility, and Development)
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Jingwei Wei Brigid Brophy Sally-Ann Cole Shane Leath Bj örn Oback Jens Boch David N Wells G ötz Laible Source Type: research

Understanding placentation in ruminants: a review focusing on cows and sheep
Reprod Fertil Dev. 2023 Dec;36(2):93-111. doi: 10.1071/RD23119.ABSTRACTMammals differ regarding their placentae, but in all species placental trophoblasts interact intimately with the uterine endometrium to mediate the transfer of nutrients from the mother to the embryo/fetus through the closely juxtaposed microcirculatory systems of the uterus and placenta. Placentation in ruminants is intermediate between the non-invasive type, as observed in the epitheliochorial placenta of pigs, and the invasive type, as observed in the haemochorial placentae of mice and humans. In ruminants, placental trophoblast cells invade uterine ...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Gregory A Johnson Fuller W Bazer Heewon Seo Robert C Burghardt Guoyao Wu Ky G Pohler Joe W Cain Source Type: research

IETS management of the challenges associated with embryo pathogen interaction
Reprod Fertil Dev. 2023 Dec;36(2):16-26. doi: 10.1071/RD23144.ABSTRACTOne of the very first challenges the International Embryo Transfer Society (IETS) addressed was concern about disease transmission via the transfer of in vivo -derived (IVD) bovine embryos. IETS commissioned its Import/Export Committee, later named Health and Safety Advisory Committee (HASAC), to resolve this matter, with the assistance of the Data Retrieval Committee following its formation in 1991. Since its first meeting in 1984, considerable achievements have been made, including meeting the numerous challenges created by the many innovations in this...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Michel Thibier George Perry Source Type: research

Molecular and cellular programs underlying the development of bovine pre-implantation embryos
Reprod Fertil Dev. 2023 Dec;36(2):34-42. doi: 10.1071/RD23146.ABSTRACTEarly embryonic mortality is a major cause of infertility in cattle, yet the underlying molecular causes remain a mystery. Over the past half century, assisted reproductive technologies such as in vitro fertilisation and somatic cell nuclear transfer have been used to improve cattle reproductive efficiency; however, reduced embryo developmental potential is seen compared to their in vivo counterparts. Recent years have seen exciting progress across bovine embryo research, including genomic profiling of embryogenesis, new methods for improving embryo comp...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Zongliang Jiang Source Type: research

Reproduction in the era of genomics and automation
Reprod Fertil Dev. 2023 Dec;36(2):51-65. doi: 10.1071/RD23173.ABSTRACTMuch progress has been made in the reproductive efficiency of lactating dairy cows across the USA in the past 20years. The standardisation of evaluation of reproductive efficiency, particularly with greater focus on metrics with lesser momentum and less lag-time such as 21-day pregnancy rates (21-day PR), and the recognition that subpar reproductive efficiency negatively impacted profitability were major drivers for the changes that resulted in such progress. Once it became evident that the genetic selection of cattle for milk yield regardless of fertili...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Ricardo C Chebel Rafael S Bisinotto Julio Giordano Aristide Maggiolino Pasquale de Palo Source Type: research

Looking back at five decades of embryo technology in practice
Reprod Fertil Dev. 2023 Dec;36(2):1-15. doi: 10.1071/RD23120.ABSTRACTThis paper covers developments from International Embryo Technology Society (IETS) meetings over the past 50years. The IETS was officially 'born' at a meeting in Denver, Colorado on Sunday 26 May 1974. There have been 51 IETS meetings (the first was in May 1974), and the first conference at which papers were presented was in 1975. The name of the IETS was changed from International Embryo Transfer Society to International Embryo Technology Society in 2016. The annual IETS conferences are held once a year in January. Embryo technology advanced from the lab...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: John F Hasler Source Type: research

Understanding conceptus-maternal interactions: what tools do we need to develop?
Reprod Fertil Dev. 2023 Dec;36(2):81-92. doi: 10.1071/RD23181.ABSTRACTCommunication between the maternal endometrium and developing embryo/conceptus is critical to support successful pregnancy to term. Studying the peri-implantation period of pregnancy is critical as this is when most pregnancy loss occurs in cattle. Our current understanding of these interactions is limited, due to the lack of appropriate in vitro models to assess these interactions. The endometrium is a complex and heterogeneous tissue that is regulated in a transcriptional and translational manner throughout the oestrous cycle. While there are in vitro ...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Zenab Butt Haidee Tinning Mary J O'Connell Jonathan Fenn Ramiro Alberio Niamh Forde Source Type: research

Mammalian embryo culture media: now and into the future
Reprod Fertil Dev. 2023 Dec;36(2):66-80. doi: 10.1071/RD23168.ABSTRACTFor over 70years, since the culture of the first mammalian embryo in vitro , scientists have undertaken studies to devise and optimise media to support the manipulation and culture of gametes and embryos. This area of research became especially active in the late 1970s onwards following the successful birth of the first human in vitro fertilised embryo. This review summarises some of the key advances in mammalian embryo culture media over time based on a greater understanding of the biochemical milieu of the reproductive tract. It highlights how learning...
Source: Reproduction, Fertility, and Development - December 8, 2023 Category: Reproduction Medicine Authors: Deirdre L Zander-Fox Leanne Pacella-Ince Daniel K Morgan Mark P Green Source Type: research